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Ki-67 is a strong prognostic marker of non-small cell lung cancer when tissue heterogeneity is considered
http://hdl.handle.net/10232/25501
http://hdl.handle.net/10232/25501071db4b0-1f6c-4763-b60c-75d132e892db
| 名前 / ファイル | ライセンス | アクション |
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Diss_田畑_和宏_ISK19_2014.pdf (2.2 MB)
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Abstract_田畑_和宏_TO_2014.pdf (58.7 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2015-10-29 | |||||
| タイトル | ||||||
| タイトル | Ki-67 is a strong prognostic marker of non-small cell lung cancer when tissue heterogeneity is considered | |||||
| タイトル言語 | en | |||||
| 著者 |
田畑, 和宏
× 田畑, 和宏 |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Ki-67 expression is a well-established prognostic marker in various cancers. However, Ki-67 expression is also known as being heterogeneous. We investigated the prognostic significance of Ki-67 from the view of staining heterogeneity by the technique of Spiral Array. Methods: 100 cases of resected lung cancer from Toyama university hospital archive were collected. Spiral Array blocks were generated out of 100 cases using 100 μm thick paraffin sections. Four μm thick sections of the Array block were stained for Ki-67. Staining results in each reel were scored for areas with lowest (LS), highest (HS), and average (AS) expression, exclusively in the cancer cells. Heterogeneity score (HeS) was designed as the difference between HS and LS. The scores were divided into four grades (0–3). Clinical information was collected, and the prognostic significance of Ki-67 was analyzed. Results: Pathological stage was available for 91 patients (43 stage IA, 22 stage IB, 2 stage IIA, 9 stage IIB, 13 stage IIIA, 1 stage IIIB, and 1 stage IV). The HS of Ki-67 score in non-small cell lung cancer was 3 in 17 cases, 2 in 27 cases, 1 in 28 cases, 0 in 21 cases, and 4 reels were lost. 78 cases had clinical follow up. 74 cases had all the information available and were analyzed for correlation between Ki-67 expression and survival. Cases with score 2 and 3 of HS and HeS showed significant poorer prognosis (both P < 0.001), whereas LS or AS did not show significance. The results were identical when analyzing adenocarcinoma and squamous cell carcinoma, separately. Cox multivariate analysis of Ki-67 showed that HS was an independent risk factor affecting overall survival. Conclusions: Ki-67 is a strong prognostic marker for non-small cell lung cancer when the degree of highest staining frequency or heterogeneity is considered. Kazuhiro Tabata, Tomonori Tanaka, Tomayoshi Hayashi, Takashi Hori, Sayuri Nunomura, Suguru Yonezawa and Junya Fukuoka Ki-67 is a strong prognostic marker of non-small cell lung cancer when tissue heterogeneity is considered BMC Clinical Pathology 2014, 14:23 https://doi.org/10.1186/1472-6890-14-23 |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2015-09-14 | |||||
| 日付タイプ | Collected | |||||
| 権利 | ||||||
| 権利情報の言語 | en | |||||
| 権利情報 | BMC Clinical Pathology. 2014, vol.14 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | BioMed Central | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | カゴシマ ダイガク | |||||
| 出版者言語 | ja-Kana | |||||
| 備考 | ||||||
| 備考 | 【指導教員:米澤傑】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2014-12-03 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-03-18 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 乙総論第19号 | |||||
