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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Postoperative Changes in Metabolic Parameters of Patients with Surgically Controlled Acromegaly : Assessment of New Stringent Cure Criteria

http://hdl.handle.net/10232/00030352
http://hdl.handle.net/10232/00030352
8dc33ce2-2c7b-4d45-9830-723f051ab1eb
名前 / ファイル ライセンス アクション
Diss_米永_理法_ISK462_2018(出版社版).pdf Diss_米永_理法_ISK462_2018(出版社版) (864.3 kB)
license.icon
Abstract_米永_理法_4513810260_2018.pdf Abstract_米永_理法_4513810260_2018 (153.5 kB)
Result_Yonenaga_Masanori_isk_462_2018.pdf Result_Yonenaga_Masanori_isk_462_2018 (1.2 MB)
Comments_Yonenaga_Masanori_isk_462_2018.pdf Comments_Yonenaga_Masanori_isk_462_2018 (451.7 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-12-04
タイトル
タイトル Postoperative Changes in Metabolic Parameters of Patients with Surgically Controlled Acromegaly : Assessment of New Stringent Cure Criteria
別言語のタイトル
その他のタイトル 先端巨大症術後コントロール群における代謝パラメーターの変化
著者 米永, 理法

× 米永, 理法

WEKO 132177

米永, 理法

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著者よみ
姓名 ヨネナガ, マサノリ
別言語の著者
姓名 YONENAGA, Masanori
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 acromegaly
キーワード
主題言語 en
主題Scheme Other
主題 surgical cure
キーワード
主題言語 en
主題Scheme Other
主題 Cortina criteria
キーワード
主題言語 en
主題Scheme Other
主題 new consensus criteria
キーワード
主題言語 en
主題Scheme Other
主題 metabolic parameters
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 The criteria for surgical cure of acromegaly have become more stringent during the past decades and a change from Cortina to new consensus criteria has recently been proposed. However, the superiority of the new consensus over Cortina criteria with respect to postoperative metabolic parameters remains to be ascertained. We retrospectively assessed metabolic parameters, the body habitus, and other health-related parameters of 48 patients with surgically controlled acromegaly who met the Cortina criteria [normalized insulin-like growth factor-1 (IGF-1) level and nadir growth hormone (GH) level <1.0 ng/ml during postoperative oral glucose tolerance test]. The 48 patients were divided into two groups. Group A (n = 33) met the new consensus criteria (normalized IGF-1 and nadir GH level <0.4 ng/ml). Group B (n = 15) met Cortina criteria, but their nadir GH ranged from 0.4 to 1.0 ng/ml. In both groups, the level of triglyceride and homeostasis model assessment-insulin resistance (HOMA-IR) was significantly decreased 1 year after the operation (P < 0.05). High-density lipoprotein cholesterol showed a significant increase only in group B (P = 0.02). However, the two groups did not differ with respect to the postoperative improvement rate of these parameters and the other health-related parameters including body mass index, blood pressure, anterior pituitary function, and self-estimated quality of life scale. In conclusion, our findings show that with respect to changes in metabolic parameters and the body habitus assessed 1 year after surgery, the stricter consensus criteria seemed not to be superior to Cortina criteria.
収録雑誌名 Neurologia medico-chirurgica

巻 58, 号 4, p. 147-155, 発行日 2018-04-15
ISSN
収録物識別子タイプ ISSN
収録物識別子 04708105
DOI
識別子タイプ DOI
DOI 10.2176/nmc.oa.2017-0215
権利
権利情報 © 2018 by The Japan Neurosurgical Society
情報源
識別子タイプ URI
関連識別子 https://www.jstage.jst.go.jp/browse/nmc/-char/en
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 493
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 The Japan Neurosurgical Society
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:吉本幸司】
date.appl
【学位申請日】2018/2/7
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2018-09-28
学位授与番号
学位授与番号 甲総研第462号
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