{"_buckets": {"deposit": "a3ab48dc-70cd-4501-944a-6ffe023d4b01"}, "_deposit": {"created_by": 24, "id": "14536", "owners": [24], "pid": {"revision_id": 0, "type": "depid", "value": "14536"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00014536", "sets": ["86"]}, "author_link": ["132674", "132675", "132673"], "item_5_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "ホスホリルコリン舌下ならびに経鼻免疫に対する粘膜および全身免疫応答"}]}, "item_5_biblio_info_5": {"attribute_name": "収録雑誌名", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "280", "bibliographicPageStart": "273", "bibliographicVolumeNumber": "45", "bibliographic_titles": [{"bibliographic_title": "Auris Nasus Larynx"}]}]}, "item_5_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2019-02-08"}]}, "item_5_date_granted_54": {"attribute_name": "学位授与年月日 ", "attribute_value_mlt": [{"subitem_dategranted": "2019-02-26"}]}, "item_5_degree_grantor_53": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "鹿児島大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "17701", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_5_degree_name_42": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）Doctor of Philosophy in Medical Science"}]}, "item_5_description_17": {"attribute_name": "ファイル（説明）", "attribute_value_mlt": [{"subitem_description": "博士論文全文", "subitem_description_type": "Other"}, {"subitem_description": "最終試験結果の要旨", "subitem_description_type": "Other"}, {"subitem_description": "論文審査の要旨", "subitem_description_type": "Other"}, {"subitem_description": "博士論文要旨", "subitem_description_type": "Other"}]}, "item_5_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "Objective: Phosphorylcholine (PC) is a structural component of a wide variety of pathogens including Streptococcus pneumoniae and Haemophilus influenzae. Here, the immune response in mice to PC immunization via the sublingual (SL) route versus the intranasal (IN) route was investigated in terms of efficacy and safety.\nMethods: BALB/c mice were immunized with PC-keyhole limpet hemocyanin (KLH) plus cholera toxin (CT) or CT alone via the IN or SL route. The immune response generated was studied in terms of PC-specific antibody titers, interferon (IFN)-g and interleukin (IL)-4 production by CD4+ T cells, and cross-reactivity of PC-specific immunoglobulin (Ig)-A antibodies in nasal washes against S. pneumoniae and non-typeable H. influenzae.\nResults: SL and IN immunization with PC-KLH plus CT resulted in a marked increase in the levels of PC-specific, mucosal IgA and serum IgM, IgG, and IgA antibodies. Additionally, SL immunization elicited significantly higher levels of PC-specific IgG2a subclass antibodies and IFNg in serum. On the other hand, IN immunization with CT alone remarkably increased the total IgE level in serum compared with SL and IN immunization with PC-KLH plus CT. PC-specific IgA antibodies in nasal wash samples reacted to most strains of S. pneumoniae and non-typeable H. influenzae.\nConclusion: SL immunization is as effective as IN immunization to induce PC-specific immune responses and more effective than IN immunization to reduce the production of IgE and to prevent the sensitization to allergen causing type I allergy.", "subitem_description_type": "Other"}]}, "item_5_dissertation_number_55": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "乙総論第34号"}]}, "item_5_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "132674", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "マセダ, ヨシコ"}]}]}, "item_5_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "132675", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "MASEDA, Yoshiko"}]}]}, "item_5_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}, {"subitem_publisher": "鹿児島大学"}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.anl.2017.04.009", "subitem_relation_type_select": "DOI"}}]}, "item_5_relation_13": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Auris Nasus Larynx"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.sciencedirect.com/journal/auris-nasus-larynx", "subitem_relation_type_select": "URI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2017 Elsevier B.V. All rights reserved."}]}, "item_5_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "491", "subitem_subject_scheme": "NDC"}]}, "item_5_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_5_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_5_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Thesis or Dissertation"}]}, "item_5_text_44": {"attribute_name": "備考", "attribute_value_mlt": [{"subitem_text_value": "【指導教員:黒野祐一】 "}]}, "item_5_text_47": {"attribute_name": "date.appl", "attribute_value_mlt": [{"subitem_text_value": "【学位申請日】2018-11-07"}]}, "item_5_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", 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[{"subitem_subject": "Phosphorylcholine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Sublingual", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Intranasal", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Streptococcus pneumoniae", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Non-typeable Haemophilus influenzae", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Immunoglobulin E", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Mucosal and systemic immune response to sublingual or intranasal immunization with phasphorylcholine", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Mucosal and systemic immune response to sublingual or intranasal immunization with phasphorylcholine"}]}, "item_type_id": "5", "owner": "24", "path": ["86"], "permalink_uri": "http://hdl.handle.net/10232/00030438", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-03-01"}, "publish_date": "2019-03-01", "publish_status": "0", "recid": "14536", "relation": {}, "relation_version_is_last": true, "title": ["Mucosal and systemic immune response to sublingual or intranasal immunization with phasphorylcholine"], "weko_shared_id": 24}