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多孔膜状疎水化ゼラチン接着膜がラット背部創傷治癒過程に与える影響の評価
http://hdl.handle.net/10232/00031695
http://hdl.handle.net/10232/00031695687e7180-0c2b-453b-9226-f72b1751c3bd
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Diss_古閑_崇_4515810053_2020 (3.5 MB)
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Abstract_古閑_崇_4515810053_2020 (210.0 kB)
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Result_Koga_Takashi_isk_580 (217.9 kB)
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Comments_Koga_Takashi_isk_580 (110.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-09 | |||||
| タイトル | ||||||
| タイトル | Evaluation of the wound healing process in rat skin using a hexanoyl group-modified alkaline-treated gelatin porous film | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 多孔膜状疎水化ゼラチン接着膜がラット背部創傷治癒過程に与える影響の評価 | |||||
| タイトル言語 | ja | |||||
| 著者 |
古閑, 崇
× 古閑, 崇 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Hexanoyl group-modified alkaline-treated gelatin porous film | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Collagen sponge | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Scar contracture | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Wound healing | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Dressing material | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The present study investigated the wound healing process in a rat skin wound model dressed with a hexanoyl group-modified alkaline-treated gelatin porous (HxAlGltn) film with angiogenesis-inducing and strong bioadhesive properties or a collagen sponge (CS). A circular 10-mm full-thickness skin defect was created on the backs of 8-week-old rats and then dressed with a HxAlGltn film (HxAlGltn group), collagen sponge (CS group), and no dressing (control group). Wound distances and areas were assessed macroscopically at specific time points after surgery, the lengths and thicknesses of the neo-epithelium histologically, and α-smooth muscle actin (α-SMA), collagen type I, and fibronectin immunohistochemically. Wound distances and areas were significantly smaller in the HxAlGltn group than in the CS and control groups. The expression of α-SMA in myofibroblasts was significantly weaker in the HxAlGltn group than in the other groups on day 7. Furthermore, angiogenesis was prominent on days 4 and 7 in the HxAlGltn group. No significant differences were observed in the length of the neo-epithelium between all groups, whereas the thickness of the neo-epithelium was greater in the HxAlGltn group than in the CS group. The present results suggest the potential of the HxAlGltn film as a dressing material in the wound healing process of full-thickness skin defects because it reduces scar contraction and promotes angiogenesis more than CS. This is the peer reviewed version of the following article: Takashi Koga, Toshiro Kibe, Tetsushi Taguchi, Takao Fuchigami, Kazuhide Nishihara, Kiyohide Ishihata, Norifumi Nakamura. Evaluation of the wound healing process in rat skin using a hexanoyl group-modified alkaline-treated gelatin porous film Oral Science International (2021), 18(1), 40-49 © 2020 Japanese Stomatological Society which has been published in final form at https://doi.org/10.1002/osi2.1077 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2021-02-09 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Japanese Stomatological Society | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:中村典史】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2020-10-07 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(歯学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Dental Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2021-02-25 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第580号 | |||||
