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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Molecular Pathogenesis of Gene Regulation by the miR-150 Duplex : miR 150-3p Regulates TNS4 in Lung Adenocarcinoma

http://hdl.handle.net/10232/00031733
http://hdl.handle.net/10232/00031733
c6bb0031-640e-49f9-9c99-eda9679befa1
名前 / ファイル ライセンス アクション
Diss_美園_俊祐_ISK600_2020.pdf Diss_美園_俊祐_ISK600_2020 (3.8 MB)
Abstract_美園_俊祐_4517810375_2020.pdf Abstract_美園_俊祐_4517810375_2020 (27.1 kB)
Result_Misono_Shunsuke_isk_600.pdf Result_Misono_Shunsuke_isk_600 (242.0 kB)
Comments_Misono_Shunsuke_isk_600.pdf Comments_Misono_Shunsuke_isk_600 (100.5 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2021-04-15
タイトル
タイトル Molecular Pathogenesis of Gene Regulation by the miR-150 Duplex : miR 150-3p Regulates TNS4 in Lung Adenocarcinoma
別言語のタイトル
その他のタイトル miR-150 duplexによる遺伝子制御 : 肺腺癌において、miR-150-3pはTNS4を制御する
著者 美園, 俊祐

× 美園, 俊祐

WEKO 139413

美園, 俊祐

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著者よみ
姓名 ミソノ, シュンスケ
別言語の著者
姓名 MISONO, Shunsuke
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 MicroRNA
キーワード
主題言語 en
主題Scheme Other
主題 miR-150-5p
キーワード
主題言語 en
主題Scheme Other
主題 miR-150-3p
キーワード
主題言語 en
主題Scheme Other
主題 lung adenocarcinoma
キーワード
主題言語 en
主題Scheme Other
主題 TNS4
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 Abstract: Based on ourmiRNAexpression signatures, wefocused on miR-150-5p (the guide strand) and miR-150-3p (the passenger strand) to investigate their functional significance in lung adenocarcinoma (LUAD). Downregulation of miR-150 duplex was confirmed in LUAD clinical specimens. In vitro assays revealed that ectopic expression of miR-150-5p and miR-150-3p inhibited cancer cell malignancy. We performed genome-wide gene expression analyses and in silico database searches to identify their oncogenic targets in LUAD cells. A total of 41 and 26 genes were identified as miR-150-5p and miR-150-3p targets, respectively, and they were closely involved in LUAD pathogenesis. Among the targets, we investigated the oncogenic roles of tensin 4 (TNS4) because high expression of TNS4 was strongly related to poorer prognosis of LUAD patients (disease-free survival: p = 0.0213 and overall survival: p = 0.0003). Expression of TNS4 was directly regulated by miR-150-3p in LUAD cells. Aberrant expression of TNS4 was detected in LUAD clinical specimens and its aberrant expression increased the aggressiveness of LUAD cells. Furthermore, we identified genes downstream from TNS4 that were associated with critical regulators of genomic stability. Our approach (discovery of anti-tumor miRNAs and their target RNAs for LUAD) will contribute to the elucidation of molecular networks involved in the malignant transformation of LUAD.
要約(Abstract)
内容記述タイプ Other
内容記述 Shunsuke Misono, Naohiko Seki, Keiko Mizuno, Yasutaka Yamada, Akifumi Uchida, Hiroki Sanada, Shogo Moriya, Naoko Kikkawa, Tomohiro Kumamoto, Takayuki Suetsugu and Hiromasa Inoue
Molecular Pathogenesis of Gene Regulation by the miR-150 Duplex: miR-150-3p Regulates TNS4 in Lung Adenocarcinoma
Cancers 2019, 11(5), 601
https://doi.org/10.3390/cancers11050601
作成日
日付 2021-03-10
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 鹿児島大学
公開者・出版者
出版者 MDPI
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:井上博雅】
date.appl
【学位申請日】2020-11-04
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2021-03-25
学位授与番号
学位授与番号 甲総研第600号
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