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高齢消化器癌患者に対する一次化学療法の無増悪生存期間に与える因子の検討
http://hdl.handle.net/10232/00031809
http://hdl.handle.net/10232/0003180984a83a71-8661-447a-a44f-1d5a0aebe429
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Diss_中澤_潤一_ISK622_2021 (690.8 kB)
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Abstract_中澤_潤一_4516810361_2021 (74.6 kB)
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Result_Nakazawa_Junichi_isk_622 (159.4 kB)
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Comments_Nakazawa_Junichi_isk_622 (96.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-12-21 | |||||
| タイトル | ||||||
| タイトル | Analysis of factors affecting progression-free survival of first-line chemotherapy in older patients with advanced gastrointestinal cancer | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 高齢消化器癌患者に対する一次化学療法の無増悪生存期間に与える因子の検討 | |||||
| タイトル言語 | ja | |||||
| 著者 |
中澤, 潤一
× 中澤, 潤一 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Geriatric assessment | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Vulnerabilities screening tool | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Gastrointestinal cancer | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | First-line palliative chemotherapy | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Objectives: Few studies have investigated factors influencing the efficacy of chemotherapy in older patients with cancer. This study aimed to evaluate the usefulness of G8, geriatric assessment (GA), and factors measured in general clinical practice for evaluating progression-free survival (PFS) of first-line palliative chemotherapy in older patients with advanced gastrointestinal cancer. Materials and methods: This was a prospective observational study of older patients (age ≥70 years) with advanced gastrointestinal cancer. The modified cut-off value of G8 was determined by referring to two or more abnormal GA conditions. The usefulness of baseline GA and G8 (conventional and modified cut-off value) was assessed according to the efficacy (PFS and disease control rate) of the administered first-line palliative chemotherapy. Results: Overall, 93 patients were evaluated between March 2017 and February 2019. A modified G8 cut-off value of ≤12 had a sensitivity and specificity of 68.9% and 46.9%, respectively. PFS was significantly prolonged in the patients with G8 > 12, serum albumin ≥3.5 g/dl, and in whom grade ≥3 adverse events occurred. There was no significant difference in the PFS between monotherapy and combination therapy. GA was not useful for predicting PFS prolongation or the occurrence of serious adverse events in first-line treatment. Conclusion: Among older patients with advanced gastrointestinal cancer who receive first-line chemotherapy, a modified G8 cut-off value of 12 points, occurrence of grade 3 or higher adverse events, albumin levels, rather than age or performance status were predictors of PFS prolongation. Junichi Nakazawa, Machiko Kawahira, Masahiro Kawahira, Tomoko Kodama, Shiho Arima, Yuji Iwashita, Seiji Mawatari, Shinichi Hashimoto, Shuji Kanmura, Takeshi Hori, Hirohito Tsubouchi, Akio Ido Analysis of factors affecting progression-free survival of first-line chemotherapy in older patients with advanced gastrointestinal cancer Journal of Geriatric Oncology 12 (2021) 1200-1207 https://doi.org/10.1016/j.jgo.2021.05.006 |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2021-11-05 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Elsevier | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:堀剛】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2021-09-01 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2021-11-16 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第622号 | |||||
