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心血管危険因子は健常者の血栓の増大を促進する : T-TAS®を用いた解析
http://hdl.handle.net/10232/00031968
http://hdl.handle.net/10232/000319685c4187c8-6f33-4a2f-ba08-c2aa72dc835c
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Diss_尾田_悠_ISK630_2021 (1.0 MB)
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Abstract_尾田_悠_4512810050_2021 (134.9 kB)
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Result_Oda_Yu_isk_630 (126.4 kB)
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Comments_Oda_Yu_isk_630 (51.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-05-23 | |||||
| タイトル | ||||||
| タイトル | Cardiovascular risk factors are associated with augmented thrombogenicity in healthy individuals : analysis using the Total Thrombus-formation Analysis System | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 心血管危険因子は健常者の血栓の増大を促進する : T-TAS®を用いた解析 | |||||
| タイトル言語 | ja | |||||
| 著者 |
尾田, 悠
× 尾田, 悠 |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Rupture of an atherosclerotic plaque and subsequent exposure of the subendothelial prothrombotic matrix to blood cause arterial thrombosis. Circulating platelets play an indispensable role in the growth of arterial thrombi partially owing to their unique ability to adhere to the subendothelial matrix and to aggregate to each other under flow conditions. Recently, the Total Thrombus-formation Analysis System (T-TAS) was developed for ex vivo analysis of the thrombogenic potential of whole blood samples under flow conditions. Despite the potential clinical utility of the T-TAS in assessing the risk for thrombosis and bleeding, reference intervals for T-TAS analysis in healthy individuals have not been determined. Methods: In total, 122 whole blood samples were collected from healthy volunteers ranging in age from 25 to 45 years. T-TAS analysis and hematological, physiological, and lifestyle assessments were conducted in these subjects. Whole blood samples anticoagulated with hirudin were perfused into a collagen-coated microchip (PL chip). The time to 10 kPa and the area under the flow pressure curve up to 10 min (AUC10) were analyzed as representative variables for thrombogenic potential. Reference intervals, which were defined as 2.5–97.5 percentiles, were determined. Additionally, univariate and multivariate analyses were performed to identify factors associated with the AUC10 in the T-TAS. Results: The time to 10 kPa and the AUC10 widely varied, even in healthy volunteers. The reference intervals were 1.50–4.02 min and 223.4–456.8, respectively, at a shear rate of 1500 s− 1. Univariate and multivariate analyses showed that platelet counts were most significantly associated with the AUC10 of the T-TAS. The presence of one or more cardiovascular risk factors of a high body mass index, a high pulse pressure, high fasting serum glucose levels, high low-density lipoprotein-cholesterol levels, a history of smoking, and no habitual exercise, had the second largest effect on the AUC10 of the T-TAS. Conclusions: Healthy volunteers who had any cardiovascular risk factors showed augmented thrombogenicity, even in artificial uniform capillaries, compared with those without any risk factors in the T-TAS. Yuu Oda, Takashi Ito, Yoichiro Yamada, Tadashi Koga, Tomoka Nagasato, Tomoko Ohnishi-Wada, Kazuya Hosokawa, Hiroyuki Fukase, Teruto Hashiguchi and Ikuro Maruyama Cardiovascular risk factors are associated with augmented thrombogenicity in healthy individuals : analysis using the Total Thrombus-formation Analysis System Thrombosis Journal (2021) 19:88 https://doi.org/10.1186/s12959-021-00341-3 |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2022-02-07 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | BMC | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | カゴシマ ダイガク | |||||
| 出版者言語 | ja-Kana | |||||
| 備考 | ||||||
| 備考 | 【指導教員:橋口照人】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2021-12-01 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2022-02-17 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第630号 | |||||
