WEKO3
アイテム
{"_buckets": {"deposit": "6400ac0e-5442-470f-8c2e-7f6ca18fbecc"}, "_deposit": {"created_by": 29, "id": "16087", "owners": [29], "pid": {"revision_id": 0, "type": "depid", "value": "16087"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00016087", "sets": ["86"]}, "author_link": ["140631", "140630"], "item_5_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "miR-30a-5pによって制御される癌促進的分子が膵管腺癌に及ぼす影響"}]}, "item_5_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2022-02-07"}]}, "item_5_date_granted_54": {"attribute_name": "学位授与年月日 ", "attribute_value_mlt": [{"subitem_dategranted": "2022-02-17"}]}, "item_5_degree_grantor_53": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "鹿児島大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "17701", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_5_degree_name_42": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)Doctor of Philosophy in Medical Science"}]}, "item_5_description_17": {"attribute_name": "ファイル(説明)", "attribute_value_mlt": [{"subitem_description": "博士論文全文", "subitem_description_type": "Other"}, {"subitem_description": "博士論文要旨", "subitem_description_type": "Other"}, {"subitem_description": "最終試験結果の要旨", "subitem_description_type": "Other"}, {"subitem_description": "論文審査の要旨", "subitem_description_type": "Other"}]}, "item_5_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "Background/Aim: Our recent miRNA analyses revealed that miR-30a-5p has tumor-suppressive activity in pancreatic ductal adenocarcinoma (PDAC). Herein, we sought to identify tumor-suppressive genes controlled by miR-30a-5p, emphasizing on genes that are closely involved in the molecular pathogenesis of PDAC. We uncovered several novel findings regarding the pathogenesis of this disease. Materials and Methods: In silico analyses were used to identify the putative target genes of miR-30a-5p and assess their expression levels. Direct regulation of RRM2 by miR-30a-5p and its oncogenic functions were evaluated in PDAC cell lines. Overexpression of RRM2 was demonstrated in clinical samples. Results: A total of 24 putative targets were identified by in silico database analysis. High expression of 4 genes (CBFB, RRM2, AHNAK, and DCBLD1) was significantly associated with shorter survival of patients with PDAC. Functional assays demonstrated that knockdown of RRM2 attenuated the malignant phenotype of PDAC cells. Conclusion: The miR-30a-5p/RRM2 axis facilitated the malignant transformation of PDAC cells.\n\nPRAMOD NEPAL, YUTO HOZAKA, TAKAKO TANAKA, MASUMI WADA, SHUNICHI ASAI, CHIKASHI MINEMURA, TETSUYA IDICHI, TAKAAKI ARIGAMI, HIROSHI KURAHARA, NAOHIKO SEKI and TAKAO OHTSUKA\nImpact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma\nANTICANCER RESEARCH 41: 4821-4836 (2021)\nhttps://doi.org/10.21873/anticanres.15297", "subitem_description_type": "Other"}]}, "item_5_dissertation_number_55": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲総研第635号"}]}, "item_5_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "140631", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ネパール, プラモド"}]}]}, "item_5_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "International Institute of Anticancer Research"}, {"subitem_publisher": "鹿児島大学"}]}, "item_5_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "490", "subitem_subject_scheme": "NDC"}]}, "item_5_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_5_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_5_text_44": {"attribute_name": "備考", "attribute_value_mlt": [{"subitem_text_value": "【指導教員:大塚隆生】"}]}, "item_5_text_47": {"attribute_name": "date.appl", "attribute_value_mlt": [{"subitem_text_value": "【学位申請日】2021-12-01"}]}, "item_5_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "NEPAL, Pramod"}], "nameIdentifiers": [{"nameIdentifier": "140630", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-06-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Diss_プラモド_ネパール_ISK635_2021.pdf", "filesize": [{"value": "5.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 5300000.0, "url": {"label": "Diss_プラモド_ネパール_ISK635_2021", "url": "https://ir.kagoshima-u.ac.jp/record/16087/files/Diss_プラモド_ネパール_ISK635_2021.pdf"}, "version_id": "6c035929-1773-4f4e-9324-71beba9cead2"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-06-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "Abstract_プラモド_ネパール_4517810437_2021.pdf", "filesize": [{"value": "326.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 326700.0, "url": {"label": "Abstract_プラモド_ネパール_4517810437_2021", "url": "https://ir.kagoshima-u.ac.jp/record/16087/files/Abstract_プラモド_ネパール_4517810437_2021.pdf"}, "version_id": "382ef118-626a-4072-acd8-0f0dc0e0dd2f"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "Result_Pramod_Nepal_isk_635.pdf", "filesize": [{"value": "146.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 146700.0, "url": {"label": "Result_Pramod_Nepal_isk_635", "url": "https://ir.kagoshima-u.ac.jp/record/16087/files/Result_Pramod_Nepal_isk_635.pdf"}, "version_id": "89a12450-9307-4e5e-abdb-cab6db1d2db4"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 3, "filename": "Comments_Pramod_Nepal_isk_635.pdf", "filesize": [{"value": "67.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 67800.0, "url": {"label": "Comments_Pramod_Nepal_isk_635", "url": "https://ir.kagoshima-u.ac.jp/record/16087/files/Comments_Pramod_Nepal_isk_635.pdf"}, "version_id": "6946ffd0-f9a6-40e4-8af5-10594ee47876"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "microRNA", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "miR-30a-5p", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "RRM2", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pancreatic ductal adenocarcinoma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tumor-suppressor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma"}]}, "item_type_id": "5", "owner": "29", "path": ["86"], "permalink_uri": "http://hdl.handle.net/10232/00031973", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-05-26"}, "publish_date": "2022-05-26", "publish_status": "0", "recid": "16087", "relation": {}, "relation_version_is_last": true, "title": ["Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma"], "weko_shared_id": -1}
Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma
http://hdl.handle.net/10232/00031973
http://hdl.handle.net/10232/000319730679c346-f085-4f61-885c-401178561e5c
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
|
|
![]() |
|
|
![]() |
|
|
![]() |
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-05-26 | |||||
タイトル | ||||||
タイトル | Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma | |||||
別言語のタイトル | ||||||
その他のタイトル | miR-30a-5pによって制御される癌促進的分子が膵管腺癌に及ぼす影響 | |||||
著者 |
NEPAL, Pramod
× NEPAL, Pramod |
|||||
別言語の著者 | ||||||
姓名 | ネパール, プラモド | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | microRNA | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | miR-30a-5p | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | RRM2 | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | pancreatic ductal adenocarcinoma | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | tumor-suppressor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background/Aim: Our recent miRNA analyses revealed that miR-30a-5p has tumor-suppressive activity in pancreatic ductal adenocarcinoma (PDAC). Herein, we sought to identify tumor-suppressive genes controlled by miR-30a-5p, emphasizing on genes that are closely involved in the molecular pathogenesis of PDAC. We uncovered several novel findings regarding the pathogenesis of this disease. Materials and Methods: In silico analyses were used to identify the putative target genes of miR-30a-5p and assess their expression levels. Direct regulation of RRM2 by miR-30a-5p and its oncogenic functions were evaluated in PDAC cell lines. Overexpression of RRM2 was demonstrated in clinical samples. Results: A total of 24 putative targets were identified by in silico database analysis. High expression of 4 genes (CBFB, RRM2, AHNAK, and DCBLD1) was significantly associated with shorter survival of patients with PDAC. Functional assays demonstrated that knockdown of RRM2 attenuated the malignant phenotype of PDAC cells. Conclusion: The miR-30a-5p/RRM2 axis facilitated the malignant transformation of PDAC cells. PRAMOD NEPAL, YUTO HOZAKA, TAKAKO TANAKA, MASUMI WADA, SHUNICHI ASAI, CHIKASHI MINEMURA, TETSUYA IDICHI, TAKAAKI ARIGAMI, HIROSHI KURAHARA, NAOHIKO SEKI and TAKAO OHTSUKA Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma ANTICANCER RESEARCH 41: 4821-4836 (2021) https://doi.org/10.21873/anticanres.15297 |
|||||
作成日 | ||||||
日付 | 2022-02-07 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文全文 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文要旨 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 最終試験結果の要旨 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 論文審査の要旨 | |||||
公開者・出版者 | ||||||
出版者 | International Institute of Anticancer Research | |||||
公開者・出版者 | ||||||
出版者 | 鹿児島大学 | |||||
公開者よみ | ||||||
公開者よみ | カゴシマ ダイガク | |||||
公開者別名 | ||||||
公開者別名 | Kagoshima University | |||||
備考 | ||||||
備考 | 【指導教員:大塚隆生】 | |||||
date.appl | ||||||
【学位申請日】2021-12-01 | ||||||
学位名 | ||||||
学位名 | 博士(医学)Doctor of Philosophy in Medical Science | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17701 | |||||
学位授与機関名 | 鹿児島大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2022-02-17 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲総研第635号 |