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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Serine palmitoyltransferase long chain subunit 3 is associated with hepatocellular carcinoma in patients with NAFLD

http://hdl.handle.net/10232/00031976
http://hdl.handle.net/10232/00031976
f24c3ab9-7ce3-4b00-baf1-702d89e577bd
名前 / ファイル ライセンス アクション
Diss_伊集院_翔_ISK637_2021.pdf Diss_伊集院_翔_ISK637_2021 (796.3 kB)
license.icon
Abstract_伊集院_翔_4514800016_2021.pdf Abstract_伊集院_翔_4514800016_2021 (177.2 kB)
Result_Ijuin_Sho_isk_637.pdf Result_Otsuka_Tsunayuki_isk_636 (5.2 MB)
Comments_Ijuin_Sho_isk_637.pdf Comments_Otsuka_Tsunayuki_isk_636 (2.5 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-05-27
タイトル
タイトル Serine palmitoyltransferase long chain subunit 3 is associated with hepatocellular carcinoma in patients with NAFLD
別言語のタイトル
その他のタイトル SPTLC3は非アルコール性脂肪性肝疾患患者の肝発癌に関連する
著者 伊集院, 翔

× 伊集院, 翔

WEKO 140638

伊集院, 翔

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著者よみ
姓名 イジュウイン, ショウ
別言語の著者
姓名 IJUIN, Sho
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 SPTLC3
キーワード
主題言語 en
主題Scheme Other
主題 NAFLD
キーワード
主題言語 en
主題Scheme Other
主題 NASH
キーワード
主題言語 en
主題Scheme Other
主題 HCC
キーワード
主題言語 en
主題Scheme Other
主題 liver fibrosis
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 The prevalence of non‑alcoholic fatty liver disease (NAFLD) is continuously increasing, with the proportion of patients with liver carcinogenesis due to non‑alcoholic steatohepatitis (NASH) rising accordingly. Although it is important to identify individuals with hepatic carcinogenesis among patients with NAFLD, useful biomarkers have not yet been established. Previously, in a mouse model of diabetes mellitus without genetic modifications, we reported that a high‑fat diet increases serine palmitoyltransferase long chain subunit 3 (SPTLC3) expression in liver tissue, accompanied by high frequency of liver carcinogenesis. Serine palmitoyltransferase (SPT) catalyzes the metabolism of fatty acids, particularly sphingolipid synthesis, and SPTLC3 has been identified as its catalytic subunit, but its role in liver disease is unclear. In the present study, the importance of SPTLC3 in NAFLD development was investigated. SPTLC3 mRNA expression was observed in a liver cancer cell line and in liver tissues from patients with NAFLD and liver cancer. In total, 99 patients with NAFLD (66 without hepatocellular carcinoma (HCC) and 33 with HCC were recruited, having been diagnosed by liver biopsy or imaging, along with 6 healthy volunteers (HVs). Serum was collected from patients and HVs, and SPTLC3 level was assessed by ELISA. SPTLC3 expression was higher in non‑cancerous compared with that in cancerous liver tissues. Serum SPTLC3 levels were negatively correlated with platelet count and positively correlated with hyaluronic acid levels, suggesting an association with liver fibrosis. Moreover, SPTLC3 levels were significantly higher in the HCC group than in the HV and NAFLD groups. Multivariate analysis of HCC‑related factors identified platelets, alanine transferase, albumin and SPTLC3 as independent factors associated with HCC. Furthermore, in patients with other chronic liver diseases (hepatitis B and C, and alcoholic liver disease), no significant differences in serum SPTLC3 levels were observed between patients with or without HCC. Thus, SPTLC3 expression increases specifically with the progression of NAFLD. Overall, the present results indicate that SPTLC3 may be involved in the development of liver carcinogenesis during NAFLD.

Sho Ijuin, Kohei Oda, Seiichi Mawatari, Ohki Taniyama, Ai Toyodome, Haruka Sakae, Kazuaki Tabu, Kotaro Kumagai, Shuji Kanmura, Tsutomu Tamai, Akihiro Moriuchi, Hirofumi Uto, Akio Ido
Serine palmitoyltransferase long chain subunit 3 is associated with hepatocellular carcinoma in patients with NAFLD
MOLECULAR AND CLINICAL ONCOLOGY 16: 55, 2022
https://doi.org/10.3892/mco.2021.2488
作成日
日付 2022-03-04
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 Spandidos Publications
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:井戸章雄】
date.appl
【学位申請日】2022-02-02
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2022-03-11
学位授与番号
学位授与番号 甲総研第637号
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