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Ground Glass Opacity 肺がんに対する陽子線治療の臨床成績
http://hdl.handle.net/10232/00031981
http://hdl.handle.net/10232/000319814c8cdcc2-7d97-434a-afd9-59dacb21663b
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Diss_永田_一郎_ISK642_2021 (1.1 MB)
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Abstract_永田_一郎_4517810277_2021 (196.5 kB)
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Result_Nagata_Ichiro_isk_642 (4.2 MB)
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Comments_Nagata_Ichiro_isk_642 (1.9 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-05-27 | |||||
| タイトル | ||||||
| タイトル | Clinical Outcomes of Proton Beam Therapy for Ground-Glass Opacity-Type Lung Cancer | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | Ground Glass Opacity 肺がんに対する陽子線治療の臨床成績 | |||||
| タイトル言語 | ja | |||||
| 著者 |
永田, 一郎
× 永田, 一郎 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | proton therapy | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | carcinoma | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | non-small-cell lung | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | ground-glass opacity | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | adenocarcinoma | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Japan | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Purpose: Surgery is the standard treatment for early-stage non-small cell lung cancer (NSCLC), including ground-glass opacity (GGO)-type lung cancer. However, some patients are inoperable or refuse to undergo surgery. To explore whether proton beam therapy (PBT) can be an alternative to surgical resection in these patients, this study aimed to examine the retrospective treatment outcomes of patients with GGO-type lung cancer who underwent PBT. Patients and Methods: Patients with stage I NSCLC and GGOs who underwent PBT at the Medipolis Proton Therapy and Research Center (Kagoshima, Japan) between April 2011 and September 2015 were included. Patients were treated with a total dose of 66 GyE delivered in 10 fractions. Survival curves were calculated using the Kaplan–Meier method, and treatment-related adverse events (AEs) were assessed. Results: A total of 48 patients (median age: 70.9 ± 9.2 years; men: 54.2%) were analyzed, among whom 53 tumors were observed. The 3-year overall survival rate after PBT was 91.7% (95% confidence interval [CI], 79.3– 96.8%), the 3-year disease-free survival rate was 85.4% (95% CI: 71.8– 92.8%), and the 3-year local control rate among 53 tumors was 92.5% (95% CI: 81.1– 97.1%). During the 3-year follow-up period, 4 patients died, and 3 survived despite recurrence or metastasis. Common AEs were radiation pneumonitis (89.6%), rib fracture (27.1%), and cough (27.1%). None of the patients developed grade ≥ 3 treatment-related AEs. Conclusion: The results of this study suggest that PBT may be a promising alternative for patients with GGO-type lung cancer when surgical resection is not feasible, with excellent survival outcomes and tolerable treatment-related AEs. Ichiro Nagata, Takashi Ogino, Takeshi Arimura, Takashi Yoshiura Clinical Outcomes of Proton Beam Therapy for Ground-Glass Opacity-Type Lung Cancer Lung Cancer: Targets and Therapy 2020:11 105–111 https://doi.org/10.2147/LCTT.S270283 |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2022-03-04 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | DOVE Medical Press | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | カゴシマ ダイガク | |||||
| 出版者言語 | ja-Kana | |||||
| 備考 | ||||||
| 備考 | 【指導教員:吉浦敬】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2021-11-04 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2022-03-11 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第642号 | |||||
