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TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep
http://hdl.handle.net/10232/00032145
http://hdl.handle.net/10232/000321457ec3f6f0-f238-4a14-ac9a-bd3c6cfd588c
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2022-11-10 | |||||
タイトル | ||||||
タイトル | TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep | |||||
別言語のタイトル | ||||||
その他のタイトル | TRPA1は環境化学物質を検知し、忌避行動を誘発し、睡眠から覚醒させる | |||||
著者 |
米満, 亨
× 米満, 亨 |
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著者よみ | ||||||
姓名 | ヨネミツ, トオル | |||||
別言語の著者 | ||||||
姓名 | YONEMITSU, Toru | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Detecting threats and escaping before serious confrontations are important for animals to avoid danger and death. Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily, is expressed in a subset of sensory neurons and mediates nociception evoked by pungent chemicals. Using behavioral testing, we found that TRPA1 knockout mice failed to avoid entering a chamber filled with vapor of formalin, allyl isothiocyanate and acrolein. The avoidance behavior was blocked by nasal but not subcutaneous administration of a blocker to TRPA1. We also found that TRPA1 knockout mice did not wake when exposed to formalin during sleep. Additionally, the spinal trigeminal nucleus, the first relay neurons of the trigeminal system, showed massive expression of c-Fos after a brief (3 min) exposure to formalin vapor. TRPA1 seems to be a sentinel for environmental chemicals and induces avoidance behaviors and waking by way of the trigeminal system. Toru Yonemitsu, Chiharu Kuroki, Nobuaki Takahashi, Yasuo Mori, Yuichi Kanmura, Hideki Kashiwadani, Youichirou Ootsuka & Tomoyuki Kuwaki TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep Scientific Reports 3, 3100 (2013) The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: https://doi.org/10.1038/srep03100 |
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作成日 | ||||||
日付 | 2015-09-10 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文全文 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文要旨 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 最終試験結果の要旨 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 論文審査の要旨 | |||||
公開者・出版者 | ||||||
出版者 | Springer Nature | |||||
公開者・出版者 | ||||||
出版者 | 鹿児島大学 | |||||
公開者よみ | ||||||
公開者よみ | カゴシマ ダイガク | |||||
公開者別名 | ||||||
公開者別名 | Kagoshima University | |||||
備考 | ||||||
備考 | 【指導教員:上村裕一】 | |||||
date.appl | ||||||
【学位申請日】2014-09-03 | ||||||
学位名 | ||||||
学位名 | 博士(医学)Doctor of Philosophy in Medical Science | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17701 | |||||
学位授与機関名 | 鹿児島大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2015-01-28 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲総研第314号 |