{"_buckets": {"deposit": "5f77f695-6f72-40bd-a1e4-239e935817e7"}, "_deposit": {"created_by": 29, "id": "16269", "owners": [29], "pid": {"revision_id": 0, "type": "depid", "value": "16269"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00016269", "sets": ["86"]}, "author_link": ["141385", "141386", "141384"], "item_5_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "CD147/basigin のTh 細胞分化と乾癬病態形成に関する包括的研究"}]}, "item_5_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2022-11-10"}]}, "item_5_date_granted_54": {"attribute_name": "学位授与年月日 ", "attribute_value_mlt": [{"subitem_dategranted": "2022-11-17"}]}, "item_5_degree_grantor_53": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "鹿児島大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "17701", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_5_degree_name_42": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）Doctor of Philosophy in Medical Science"}]}, "item_5_description_17": {"attribute_name": "ファイル（説明）", "attribute_value_mlt": [{"subitem_description": "博士論文全文", "subitem_description_type": "Other"}, {"subitem_description": "博士論文要旨", "subitem_description_type": "Other"}, {"subitem_description": "最終試験結果の要旨", "subitem_description_type": "Other"}, {"subitem_description": "論文審査の要旨", "subitem_description_type": "Other"}]}, "item_5_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "Th17 cells play an important role in psoriasis. The differentiation of naïve CD4+ T cells into Th17 cells depends on glycolysis as the energy source. CD147/basigin, an integral transmembrane protein belonging to the immunoglobulin superfamily, regulates glycolysis in association with monocarboxylate transporters (MCTs)-1 and -4 in cancer cells and T cells. We examined whether CD147/basigin is involved in the pathogenesis of psoriasis in humans and psoriasis-model mice. The serum level of CD147 was increased in patients with psoriasis, and the expression of CD147 and MCT-1 was elevated in their dermal CD4+ RORγt+ T cells. In vitro, the potential of naïve CD4+ T cells to differentiate into Th17 cells was abrogated in CD147−/− T cells. Imiquimod (IMQ)-induced psoriatic dermatitis was significantly milder in CD147−/− mice and bone marrow chimeric mice lacking CD147 in the hematopoietic cells of myeloid lineage. These findings demonstrate that CD147 is essential for the development of psoriasis via the induction of Th17 cell differentiation.\n\nAoi Okubo, Youhei Uchida, Yuko Higashi, Takuya Sato, Youichi Ogawa,  Akihiro Ryuge, Kenji Kadomatsu and Takuro Kanekura\nCD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation\nInternational Journal of Molecular Sciences 2022, 23, 177\nhttps://doi.org/10.3390/ijms23010177", "subitem_description_type": "Other"}]}, "item_5_dissertation_number_55": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲総研第678号"}]}, "item_5_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "141385", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "オオクボ, アオイ"}]}]}, "item_5_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "141386", "nameIdentifierScheme": "WEKO"}], "names": [{"name": 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"subitem_subject_scheme": "Other"}, {"subitem_subject": "psoriasis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Th17", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "monocarboxylate transporter (MCT)", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glycolysis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "CD147 Is Essential for the Development of Psoriasis via the 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