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新しいモニタリングシステムを用いた非ヒト霊長類脳梗塞モデルの定量的行動評価
http://hdl.handle.net/10232/00032426
http://hdl.handle.net/10232/00032426438d40c9-f19e-45b4-9b4e-9aff201477ee
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Diss_廣畑_俊和_ISK698_2022 (5.9 MB)
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Abstract_廣畑_俊和_4520810288_2022 (102.9 kB)
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Result_HIROHATA_Toshikazu_isk_698 (119.4 kB)
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Comments_HIROHATA_Toshikazu_isk_698 (58.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-03-14 | |||||
| タイトル | ||||||
| タイトル | Quantitative behavioral evaluation of a non-human primate stroke model using a new monitoring system | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 新しいモニタリングシステムを用いた非ヒト霊長類脳梗塞モデルの定量的行動評価 | |||||
| タイトル言語 | ja | |||||
| 著者 |
廣畑, 俊和
× 廣畑, 俊和 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | stroke | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | photothrombosis | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | non-human primate | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | behavioral analysis | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Kinect | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Recently, the common marmoset (Callithrix jacchus) has attracted significant interest as a non-human primate stroke model. Functional impairment in non-human primate stroke models should be evaluated quantitatively and successively after stroke, but conventional observational assessments of behavior cannot fully fit this purpose. In this paper, we report a behavioral analysis using MarmoDetector, a three-dimensional motion analysis, in an ischemic stroke model using photosensitive dye, along with an observational behavioral assessment and imaging examination. Methods: Ischemic stroke was induced in the left hemisphere of three marmosets. Cerebral infarction was induced by intravenous injection of rose bengal and irradiation with green light. The following day, the success of the procedure was confirmed by magnetic resonance imaging (MRI). The distance traveled, speed, activity time, and jumps/climbs were observed for 28 days after stroke using MarmoDetector. We also assessed the marmosets’ specific movements and postural abnormalities using conventional neurological scores. Results: Magnetic resonance imaging diffusion-weighted and T2-weighted images showed hyperintense signals, indicating cerebral infarction in all three marmosets. MarmoDetector data showed that the both indices immediately after stroke onset and gradually improved over weeks. Neurological scores were the worst immediately after stroke and did not recover to pre-infarction levels during the observation period (28 days). A significant correlation was observed between MarmoDetector data and conventional neurological scores. Conclusion: In this study, we showed that MarmoDetector can quantitatively evaluate behavioral changes in the acute to subacute phases stroke models. This technique can be practical for research on the pathophysiology of ischemic stroke and for the development of new therapeutic methods. Toshikazu Hirohata, Takaya Kitano, Chizu Saeki, Kousuke Baba, Fumiaki Yoshida, Takashi Kurihara, Katsuhiro Harada, Shigeyoshi Saito, Hideki Mochizuki and Megumi Shimodozono Quantitative behavioral evaluation of a non-human primate stroke model using a new monitoring system Frontiers in Neuroscience. 16:964928 https://doi.org/10.3389/fnins.2022.964928 |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2023-03-03 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Frontiers | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:下堂薗恵】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2022-11-02 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2023-03-10 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第698号 | |||||
