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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis

http://hdl.handle.net/10232/00032539
http://hdl.handle.net/10232/00032539
5cd39329-45c2-4a5c-a360-846e5d000d1b
名前 / ファイル ライセンス アクション
Diss_霧島_茉莉_ISK699_2023.pdf Diss_霧島_茉莉_ISK699_2023 (1.9 MB)
Abstract_霧島_茉莉_4517810141_2023.pdf Abstract_霧島_茉莉_4517810141_2023 (34.8 kB)
Result_KIRISHIMA_Mari_isk_699.pdf Result_KIRISHIMA_Mari_isk_699 (106.8 kB)
Comments_KIRISHIMA_Mari_isk_699.pdf Comments_KIRISHIMA_Mari_isk_699 (54.3 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2023-04-28
タイトル
タイトル Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis
別言語のタイトル
その他のタイトル 胆嚢微生物叢と膵胆管・胆嚢がんの予後との関連
著者 霧島, 茉莉

× 霧島, 茉莉

WEKO 142790

霧島, 茉莉

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著者よみ
姓名 キリシマ, マリ
別言語の著者
姓名 KIRISHIMA, Mari
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 Pancreaticobiliary tract
キーワード
主題言語 en
主題Scheme Other
主題 Gallbladder
キーワード
主題言語 en
主題Scheme Other
主題 Cancer
キーワード
主題言語 en
主題Scheme Other
主題 Bile
キーワード
主題言語 en
主題Scheme Other
主題 Microbiota
キーワード
主題言語 en
主題Scheme Other
主題 Alpha diversity
キーワード
主題言語 en
主題Scheme Other
主題 Beta diversity
キーワード
主題言語 en
主題Scheme Other
主題 Overall survival
キーワード
主題言語 en
主題Scheme Other
主題 Prognosis
キーワード
主題言語 en
主題Scheme Other
主題 Biomarker
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 Background: The microbial population of the intestinal tract and its relationship to specific diseases has been extensively studied during the past decade. However, reports characterizing the bile microbiota are rare. This study aims to investigate the microbiota composition in patients with pancreaticobiliary cancers and benign diseases by 16S rRNA gene amplicon sequencing and to evaluate its potential value as a biomarker for the cancer of the bile duct, pancreas, and gallbladder.
Results: We enrolled patients who were diagnosed with cancer, cystic lesions, and inflammation of the pancreaticobiliary tract. The study cohort comprised 244 patients. We extracted microbiome-derived DNA from the bile juice in surgically resected gallbladders. The microbiome composition was not significantly different according to lesion position and cancer type in terms of alpha and beta diversity. We found a significant difference in the relative abundance of Campylobacter, Citrobacter, Leptotrichia, Enterobacter, Hungatella, Mycolicibacterium, Phyllobacterium and Sphingomonas between patients without and with lymph node metastasis.
Conclusions: There was a significant association between the relative abundance of certain microbes and overall survival prognosis. These microbes showed association with good prognosis in cholangiocarcinoma, but with poor prognosis in pancreatic adenocarcinoma, and vice versa. Our findings suggest that pancreaticobiliary tract cancer patients have an altered microbiome composition, which might be a biomarker for distinguishing malignancy.

Mari Kirishima, Seiya Yokoyama, Kei Matsuo, Taiji Hamada, Michiko Shimokawa, Toshiaki Akahane, Tomoyuki Sugimoto, Hirohito Tsurumaru, Matsujiro Ishibashi, Yuko Mataki, Takao Ootsuka, Mitsuharu Nomoto, Chihiro Hayashi, Akihiko Horiguchi, Michiyo Higashi & Akihide Tanimoto
Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis
BMC Microbiology (2022) 22:147
https://doi.org/10.1186/s12866-022-02557-3
作成日
日付 2023-04-10
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 BioMed Central
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:谷本昭英】
date.appl
【学位申請日】2022-12-07
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2023-04-18
学位授与番号
学位授与番号 甲総研第699号
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