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乳癌の分子的病因 : 発癌遺伝子に対するmiR-99a-5p およびmiR-99a-3p調節の影響
http://hdl.handle.net/10232/00032540
http://hdl.handle.net/10232/000325402301526c-ccfb-46cf-adfe-823b3a9a9887
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Digest_平島_忠寛_ISK700_2023 (1.1 MB)
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Abstract_平島_忠寛_4517810311_2023 (37.0 kB)
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Result_HIRASHIMA_Tadahiro_isk_700 (160.8 kB)
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Comments_HIRASHIMA_Tadahiro_isk_700 (68.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-04-28 | |||||
| タイトル | ||||||
| タイトル | Molecular pathogenesis of breast cancer: impact of miR-99a-5p and miR-99a-3p regulation on oncogenic genes | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 乳癌の分子的病因 : 発癌遺伝子に対するmiR-99a-5p およびmiR-99a-3p調節の影響 | |||||
| タイトル言語 | ja | |||||
| 著者 |
平島, 忠寛
× 平島, 忠寛 |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Our recent research has revealed that passenger strands of certain microRNAs (miRNAs) function as tumor-suppressive miRNAs in cancer cells, e.g., miR-101-5p, miR-143-5p, miR-144-5p, miR-145-3p, and miR-150-3p. Thus, they are important in cancer pathogenesis. Analysis of the miRNA expression signature of breast cancer (BrCa) showed that the expression levels of two miRNAs derived from pre-miR-99a (miR-99a-5p and miR-99a-3p) were suppressed in cancerous tissues. The aim of this study was to identify oncogenic genes controlled by pre-miR-99a that are closely involved in the molecular pathogenesis of BrCa. A total of 113 genes were identified as targets of pre-miR-99a regulation (19 genes modulated by miR-99a-5p, and 95 genes regulated by miR-99a-3p) in BrCa cells. Notably, FAM64A was targeted by both of the miRNAs. Among these targets, high expression of 16 genes (C5orf22, YOD1, SLBP, F11R, C12orf49, SRPK1, ZNF250, ZNF695, CDK1, DNMT3B, TRIM25, MCM4, CDKN3, PRPS, FAM64A, and DESI2) significantly predicted reduced survival of BrCa patients based upon The Cancer Genome Atlas (TCGA) database. In this study, we focused on FAM64A and investigated the relationship between FAM64A expression and molecular pathogenesis of BrCa subtypes. The upregulation of FAM64A was confirmed in BrCa clinical specimens. Importantly, the expression of FAM64A significantly differed between patients with Luminal-A and Luminal-B subtypes. Our data strongly suggest that the aberrant expression of FAM64A is involved in the malignant transformation of BrCa. Our miRNA-based approaches (identification of tumor-suppressive miRNAs and their controlled targets) will provide novel information regarding the molecular pathogenesis of BrCa. Yoshiaki Shinden, Tadahiro Hirashima, Nijiro Nohata, Hiroko Toda, Reona Okada, Shunichi Asai, Takako Tanaka, Yuto Hozaka, Takao Ohtsuka, Yuko Kijima & Naohiko Seki Molecular pathogenesis of breast cancer: impact of miR-99a-5p and miR-99a-3p regulation on oncogenic genes Journal of Human Genetics 66, 519–534 (2021) This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s10038-020-00865-y |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2023-04-10 | |||||
| 日付タイプ | Collected | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文要約, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Springer Nature | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | カゴシマ ダイガク | |||||
| 出版者言語 | ja-Kana | |||||
| 備考 | ||||||
| 備考 | 【指導教員:大塚隆生】要約公表の理由: 出版社版が公開不可のため | |||||
| date.appl | ||||||
| appl | 【学位申請日】2022-11-02 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2023-04-18 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第700号 | |||||
