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Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung Cancer Progression and Prognosis: A Retrospective Cohort Study
http://hdl.handle.net/10232/00032553
http://hdl.handle.net/10232/000325538d0c061f-6a00-4dae-a897-834f91b124a1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
11795549_v13_p1-6 (482.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-06-02 | |||||
| タイトル | ||||||
| タイトル | Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung Cancer Progression and Prognosis: A Retrospective Cohort Study | |||||
| タイトル言語 | en | |||||
| 著者 |
Aoki, Masaya
× Aoki, Masaya× Umehara, Tadashi× Kamimura, Go× Imamura, Nobuhiro× Morizono, Shoichiro× Nonaka, Yuto× Tokunaga, Takuya× Takeda, Aya× Maeda, Koki× Watanabe, Yui× Nagata, Toshiyuki× Otsuka, Tsunayuki× Yokomakura, Naoya× Kariatsumari, Kota× Yanagi, Masakazu× Sato, Masami |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | BMP-7 | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | non-small cell lung cancer | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | complete resection | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | lymph node metastasis | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | prognosis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Bone morphogenetic protein-7 (BMP-7) is a signaling molecule belonging to the transforming growth factor-β superfamily. Recent studies have demonstrated that BMP-7 is expressed in various human cancers and plays an important role in the progression of their cancers. The purpose of this study was to investigate the clinicopathologic and prognostic impact of BMP-7 expression in clinical samples of non-small cell lung cancer. Methods: This study enrolled 160 patients with non-small cell lung cancer who underwent complete resection. Expression of BMP-7 in cancer tissue was evaluated by immunohistochemistry. Correlations between expression of BMP-7 and clinicopathologic factors and prognosis were analyzed. Results: In non-small cell lung cancer, BMP-7 expression was identified not only in cell membranes but also in the cytoplasm of cancer cells. Expression of BMP-7 correlated with p-T (P = .047), N factor (P = .013), and p-stage (P = .046). Overall survival rate was significantly lower in the BMP-7-positive group than in the BMP-7-negative group (P = .004). Multivariate analysis indicated that BMP-7 expression was one of the independent prognosis factors of overall survival (P = .021). Furthermore, among patients with postoperative recurrence (n = 58), the BMP-7-positive group (n = 29) had a significantly poorer prognosis than the BMP-7-negative group (n = 29) (P = .012). Conclusions: Expression of BMP-7 in non-small cell lung cancer was correlated with clinicopathologic factors and poorer prognosis. BMP-7 expression may be a useful predictor of aggressive activity of tumor behavior and postoperative outcome of patients with non-small cell lung cancer. Masaya Aoki, Tadashi Umehara, Go Kamimura, Nobuhiro Imamura, Shoichiro Morizono, Yuto Nonaka, Takuya Tokunaga, Aya Harada Takeda, Koki Maeda, Yui Watanabe, Toshiyuki Nagata, Tsunayuki Otsuka, Naoya Yokomakura, Kota Kariatsumari, Masakazu Yanagi and Masami Sato Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung Cancer Progression and Prognosis: A Retrospective Cohort Study Clinical Medicine Insights: Oncology Volume 13: 1–6 https://doi.org/10.1177/1179554919852087 |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Clinical Medicine Insights: Oncology 巻 13, p. 1-6, 発行日 2019-05-28 |
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| 作成日 | ||||||
| 日付 | 2019-05-28 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| ISSN | 11795549 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| 公開者・出版者 | ||||||
| 出版者 | SAGE Publications | |||||
| 出版者言語 | en | |||||
