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  1. 医歯学総合研究科
  2. 医歯学総合研究科・学術誌論文

Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung Cancer Progression and Prognosis: A Retrospective Cohort Study

http://hdl.handle.net/10232/00032553
http://hdl.handle.net/10232/00032553
8d0c061f-6a00-4dae-a897-834f91b124a1
名前 / ファイル ライセンス アクション
11795549_v13_p1-6.pdf 11795549_v13_p1-6 (482.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-06-02
タイトル
タイトル Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung Cancer Progression and Prognosis: A Retrospective Cohort Study
タイトル言語 en
著者 Aoki, Masaya

× Aoki, Masaya

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en Aoki, Masaya

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Umehara, Tadashi

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en Umehara, Tadashi

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Kamimura, Go

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Imamura, Nobuhiro

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en Imamura, Nobuhiro

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Morizono, Shoichiro

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Nonaka, Yuto

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Tokunaga, Takuya

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Takeda, Aya

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Maeda, Koki

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Watanabe, Yui

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Nagata, Toshiyuki

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Otsuka, Tsunayuki

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Yokomakura, Naoya

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Kariatsumari, Kota

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Yanagi, Masakazu

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Sato, Masami

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言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 BMP-7
キーワード
主題言語 en
主題Scheme Other
主題 non-small cell lung cancer
キーワード
主題言語 en
主題Scheme Other
主題 complete resection
キーワード
主題言語 en
主題Scheme Other
主題 lymph node metastasis
キーワード
主題言語 en
主題Scheme Other
主題 prognosis
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約
内容記述タイプ Other
内容記述 Background: Bone morphogenetic protein-7 (BMP-7) is a signaling molecule belonging to the transforming growth factor-β superfamily. Recent studies have demonstrated that BMP-7 is expressed in various human cancers and plays an important role in the progression of their cancers. The purpose of this study was to investigate the clinicopathologic and prognostic impact of BMP-7 expression in clinical samples of non-small cell lung cancer.
Methods: This study enrolled 160 patients with non-small cell lung cancer who underwent complete resection. Expression of BMP-7 in cancer tissue was evaluated by immunohistochemistry. Correlations between expression of BMP-7 and clinicopathologic factors and prognosis were analyzed.
Results: In non-small cell lung cancer, BMP-7 expression was identified not only in cell membranes but also in the cytoplasm of cancer cells. Expression of BMP-7 correlated with p-T (P = .047), N factor (P = .013), and p-stage (P = .046). Overall survival rate was significantly lower in the BMP-7-positive group than in the BMP-7-negative group (P = .004). Multivariate analysis indicated that BMP-7 expression was one of the independent prognosis factors of overall survival (P = .021). Furthermore, among patients with postoperative recurrence (n = 58), the BMP-7-positive group (n = 29) had a significantly poorer prognosis than the BMP-7-negative group (n = 29) (P = .012).
Conclusions: Expression of BMP-7 in non-small cell lung cancer was correlated with clinicopathologic factors and poorer prognosis. BMP-7 expression may be a useful predictor of aggressive activity of tumor behavior and postoperative outcome of patients with non-small cell lung cancer.

Masaya Aoki, Tadashi Umehara, Go Kamimura, Nobuhiro Imamura, Shoichiro Morizono, Yuto Nonaka, Takuya Tokunaga, Aya Harada Takeda, Koki Maeda, Yui Watanabe, Toshiyuki Nagata, Tsunayuki Otsuka, Naoya Yokomakura, Kota Kariatsumari, Masakazu Yanagi and Masami Sato
Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung Cancer Progression and Prognosis: A Retrospective Cohort Study
Clinical Medicine Insights: Oncology Volume 13: 1–6
https://doi.org/10.1177/1179554919852087
内容記述言語 en
収録雑誌名 en : Clinical Medicine Insights: Oncology

巻 13, p. 1-6, 発行日 2019-05-28
作成日
日付 2019-05-28
日付タイプ Issued
ISSN
収録物識別子タイプ EISSN
ISSN 11795549
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
公開者・出版者
出版者 SAGE Publications
出版者言語 en
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