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マウスモデルにおいて骨髄内骨髄移植は移植後非感染性肺合併症の発症を予防する
http://hdl.handle.net/10232/0002000002
http://hdl.handle.net/10232/0002000002c2d88e5d-47ca-4dee-a561-89c518a045e5
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Diss_山筋_好子_ISK705_2023 (2.25 MB)
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Abstract_山筋_好子_4508810035_2023 (124 KB)
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Result_MAEDA_Yoshiko_isk_705.pdf (163 KB)
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Comments_MAEDA_Yoshiko_isk_705.pdf (56 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-09-26 | |||||
| タイトル | ||||||
| タイトル | Prevention of non-infectious pulmonary complications after intra-bone marrow stem cell transplantation in mice | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | マウスモデルにおいて骨髄内骨髄移植は移植後非感染性肺合併症の発症を予防する | |||||
| タイトル言語 | ja | |||||
| 著者 |
山筋, 好子
× 山筋, 好子 |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Non-infectious pulmonary complications including idiopathic pneumonia syndrome (IPS) and bronchiolitis obliterans syndrome (BOS), which are clinical and diagnostic manifestations of lung chronic graft-versus-host disease (GVHD), cause significant mortality after allogeneic stem cell transplantation (SCT). Increasing evidence suggests that alloantigen reactions in lung tissue play a central role in the pathogenesis of IPS and BOS; however, the mechanism is not fully understood. Several clinical and experimental studies have reported that intra-bone marrow (IBM)-SCT provides high rates of engraftment and is associated with a low incidence of acute GVHD. In the present study, allogeneic SCT was conducted in mouse models of IPS and BOS, to compare intravenous (IV)-SCT with IBM-SCT. Allogeneic IBM-SCT improved the clinical and pathological outcomes of pulmonary complications compared to those of IV-SCT. The mechanisms underlying the reductions in pulmonary complications in IBM-SCT mice were explored. The infiltrating lung cells were mainly CD11b+ myeloid and CD3+ T cells, in the same proportions as in transplanted donor cells. In an in vivo bioluminescence imaging, a higher proportion of injected donor cells was detected in the lung during the early phase (1 h after IV-SCT) than after IBM-SCT (16.7 ± 1.1 vs. 3.1 ± 0.7 × 105 photons/s/animal, IV-SCT vs. IBM-SCT, P = 1.90 × 10−10). In the late phase (5 days) after SCT, there were also significantly more donor cells in the lung after IV-SCT than after IBM-SCT or allogeneic-SCT (508.5 ± 66.1 vs. 160.1 ± 61.9 × 106 photons/s/animal, IV-SCT vs. IBM-SCT, P = 0.001), suggesting that the allogeneic reaction induces sustained donor cell infiltration in the lung during the late phase. These results demonstrated that IBM-SCT is capable of reducing injected donor cells in the lung; IBM-SCT decreases donor cell infiltration. IBM-SCT therefore represents a promising transplantation strategy for reducing pulmonary complications, by suppressing the first step in the pathophysiology of chronic GVHD. | |||||
| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Yoshiko Yamasuji-Maeda,Hisakazu Nishimori,Keisuke Seike,Akira Yamamoto,Hideaki Fujiwara,Taiga Kuroi,Kyosuke Saeki,Haruko Fujinaga,Sachiyo Okamoto,Ken-ichi Matsuoka,Nobuharu Fujii,Takehiro Tanaka,Masahiro Fujii,Katsumi Mominoki,Takuro Kanekura,Yoshinobu Maeda Prevention of non-infectious pulmonary complications after intra-bone marrow stem cell transplantation in mice PLoS ONE 17(9):e0273749 https://doi.org/10.1371/journal.pone.0273749 |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2023-07-07 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | PLOS | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:金蔵拓郎】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2023-03-01 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2023-07-19 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第705号 | |||||
