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基盤的な哺乳類の実験動物を使った、臼歯群の歯冠形態と咬頭の相同性に関する発生学的研究
http://hdl.handle.net/10232/0002000350
http://hdl.handle.net/10232/0002000350ba65ca6d-f2fd-47d4-9f7d-91a33af40140
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2024-06-07 | |||||
| タイトル | ||||||
| タイトル | Developmental investigation on molar morphology and cusp homology using a mammalian basal model organism | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 基盤的な哺乳類の実験動物を使った、臼歯群の歯冠形態と咬頭の相同性に関する発生学的研究 | |||||
| タイトル言語 | ja | |||||
| 著者 |
Haider Md Yasin
× Haider Md Yasin |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | mammal teeth | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cusp homology | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | phylogeny | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | ontogeny | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | recapitulation | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | gene expression | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | tooth type | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Phylogenetically, the evolutionary journey of mammalian dentition from the simple, single-cusped conical teeth seen in reptiles to the more complex multi-cusped tribosphenic molars in marsupial and placental mammals involved the gradual addition of new cusps. Ontogenetically, the intricate formation of these complex mammalian molars occurs through the dynamic interaction between the dental epithelium and the mesenchyme, particularly the interface area that will ultimately become the enamel-dentin junction. This interface becomes complex by adding signaling centers, enamel knots, which determine future cusp positions. A parallel relationship between ontogeny and phylogeny of the mammalian multi-cusped teeth has been expected. Meanwhile, the ‘premolar analogy theory’ proposes homology between certain premolar and molar cusps in humans, despite lacking substantive evidence to substantiate this claim. To shed light on these theories and concepts our study focused on the developmental process of multi-cusped teeth in the house shrew (Suncus murinus), a living placental mammal species with molar morphologies considered the least derived from the tribosphenic prototype among mammals. This research aimed to uncover the evolutionary origins of cusp formation and their relationship to development and to discover the homology of these cusps. The findings of this study were enlightening. The first formed enamel knots gave rise to the evolutionarily oldest cusps, the upper paracone and the lower protoconid. The order of enamel knot formation in development precisely followed the order of cusp appearance in evolution. The parallel relationship between ontogeny and phylogeny of mammalian molars suggests that some heterochronic changes during tooth morphogenesis should have been a causal factor in the evolutionary transformation of tooth morphology. Furthermore, the study unearthed a novel perspective on dental homology within the cusps of house shrew's dentition. The large buccal cusp of the premolar is homologous to the single cusp of the canine and mesiobuccal cusp (paracone) of the molar. Our result also suggested that molar morphology formed by duplicating the premolar morphogenetic process in the distal direction during the odontogenesis process. This concept underscores the intricacy of tooth development, offering a fresh perspective on the evolution of dental cusps. |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2024-03-08 | |||||
| 日付タイプ | Collected | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Kagoshima University | |||||
| 出版者言語 | en | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:田中達朗】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2024-02-07 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(歯学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Dental Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2024-03-15 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第729号 | |||||
