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運動はOncostatin Mを介して頭頸部扁平上皮癌の増殖を抑制する
http://hdl.handle.net/10232/0002000365
http://hdl.handle.net/10232/000200036540005216-6343-4803-ac3f-016c20716681
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Diss_HIRANO_Yuka_ISK747_2024.pdf (2.5 MB)
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Abstract_HIRANO_Yuka_4520810279_2024.pdf (26.1 KB)
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Result_HIRANO_Yuka_isk_747 (153 KB)
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Comments_HIRANO_Yuka_isk_747 (64.2 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2024-07-03 | |||||
| タイトル | ||||||
| タイトル | Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 運動はOncostatin Mを介して頭頸部扁平上皮癌の増殖を抑制する | |||||
| タイトル言語 | ja | |||||
| 著者 |
平野, 憂花
× 平野, 憂花 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | exercise | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | myokine | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | head and neck squamous cell carcinoma | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | oncostatin M | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | sarcopenia | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Major advances have been made in cancer treatment, but the prognosis for elderly cancer patients with sarcopenia and frailty remains poor. Myokines, which are thought to exert preventive effects against sarcopenia, have been reported to be associated with the prognosis of various cancers, but their effect on head and neck squamous cell carcinoma (HNSCC) is unknown. The aim of this study was to clarify the influence of exercise on the control of HNSCC and to examine the underlying mechanism involved. Mice were injected with HSC-3-M3 cells, a human cell line of highly metastatic and poorly differentiated tongue cancer, at the beginning of the study. Just prior to transplantation, blood was collected from the mice, and the levels of myokines were measured by ELISA. Oncostatin M (OSM), a selected myokine, was added to HSC-3-M3 cells, after which the cell proliferation ability, cell cycle, and protein expression were analyzed in vitro. Tumor cell viability was lower (control: 100%, exercise: 75%), tumors were smaller (control: 26.2 mm3, exercise: 6.4 mm3), and survival was longer in the exercise group than in the control group in vivo. OSM inhibited HSC-3-M3 cell proliferation in a concentration-dependent manner in vitro. The addition of OSM increased the proportion of cells in the G0/G1 phase, decreased the proportion of cells in the G2/M phase, and increased the expression of the CDK inhibitors p21 and p27. These results indicate that exercise may directly inhibit the proliferation of HNSCC cell lines via OSM. | |||||
| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Yoshimura, T., Hirano, Y., Hamada, T., Yokoyama, S., Suzuki, H., Takayama, H., Migita, H., Ishida, T., Nakamura, Y., Ohsawa, M., Asakawa, A., Ishihata, K., & Tanimoto, A. (2024). Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M. Cancers, 16(6), 1187. https://doi.org/10.3390/cancers16061187 | |||||
| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2024-06-06 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | MDPI | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:田中達朗】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2024-05-08 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(歯学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Dental Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2024-06-19 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第747号 | |||||
