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アイテム
A simple method that doubles learning speed for mice in touchscreen-based visual discrimination.
http://hdl.handle.net/10232/0002002565
http://hdl.handle.net/10232/0002002565330071c1-bd55-429c-aebf-67f9c8fde19e
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Kiyama-etal-SciRep-2025.pdf (2.6 MB)
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Supplemental_Information_Kiyama_et_al.pdf (1.1 MB)
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SI Movie S1.mp4 (4.8 MB)
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SI Movie S2.mp4 (4.7 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2026-06-15 | |||||
| タイトル | ||||||
| タイトル | A simple method that doubles learning speed for mice in touchscreen-based visual discrimination. | |||||
| タイトル言語 | en | |||||
| 著者 |
城山, 優治
× 城山, 優治× Suzuki, Yusuke× 原口, みさ子× Oe, Yukimura× Daitoku, Yukihisa× Higa, Natsumi× 入江, 良彦× 鈴木, 健× Imayoshi, Itaru× Kakeyama, Masaki× 奥野, 浩行 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Operant learning | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Visual discrimination | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cognitive flexibility | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Touchscreen-based operant learning systems are widely used in behavioral neuroscience to assess cognitive function across various animal models, including mice. However, conventional training protocols for visual discrimination (VD) tasks in mice often require extended training periods. We developed modified touchscreen training protocols that enhance learning efficiency in VD tasks. Our method requires mice to perform two or three consecutive screen touches to confirm their stimulus selection. If inconsistent responses occur during these touches, the trial is reset. This approach significantly improved task acquisition speed. Additionally, we incorporated visual feedback after incorrect choices, which further enhanced learning speed and task accuracy. Using this protocol, mice rapidly acquired both initial VD learning and reversal learning, even with multiple randomly presented stimulus pairs. Furthermore, in serial reversal tasks, mice exhibited improved performance across sessions, indicating rule acquisition and cognitive flexibility. These findings demonstrate that simple protocol adjustments can significantly improve touchscreen-based cognitive assessments in mice, enabling more cognitively demanding behavioral experiments in preclinical research. | |||||
| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Scientific reports 巻 15, 号 1, p. 43133, 発行日 2025-12-03 |
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| 作成日 | ||||||
| 日付 | 2025-12-03 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| ISSN | 20452322 | |||||
| PubMed Id | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| PubMed Id | 41339645 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1038/s41598-025-27003-y | |||||
| 権利 | ||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 権利情報 | © The Author(s) 2025 / This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. | |||||
| 権利情報の言語 | en | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ファイル（説明） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 本文, Supplementary Information, Supplementary Video | |||||
| 言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Nature Research | |||||
| 出版者言語 | en | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 関連タイプ | isSupplementedBy | |||||
| 識別子タイプ | HDL | |||||
| 関連識別子 | http://hdl.handle.net/10232/0002002190 | |||||
