| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-08-31 |
| タイトル |
|
|
タイトル |
Effects of Ninjin’yoeito and physical exercise on serum corticosterone and hippocampal BDNF/proBDNF and neuroinflammation in post-stroke depression in rats |
|
タイトル言語 |
en |
| 著者 |
榊間, 春利
Nojima, Nao
谷, 明
中西, 和毅
Matsuoka, Teruki
Matsuzaki, Ryoma
Kakimoto, Shogo
Kato, Yuki
Tachibe, Yuta
Inadome, Masaki
Kawatani, Takuya
Otsuka, Shotaro
Mizuno, Keita
丸山, 征郎
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PSD |
| キーワード |
|
|
主題言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Ninjin’yoeito |
| キーワード |
|
|
主題言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Neurotrophic factor |
| キーワード |
|
|
主題言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Neurogenesis |
| キーワード |
|
|
主題言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Neuroinflammation |
| キーワード |
|
|
主題言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Rehabilitation |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 要約 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Background: Ninjin’yoeito (NYT), a traditional Japanese Kampo medicine, improves the depression and anxiety in humans and animals, rendering it a novel therapeutic option for post-stroke depression (PSD). Furthermore, physical exercise is an important nonpharmacological therapy for major depressive disorder. The components of NYT or exercise exert antidepressant effects through the increased expression of neurotrophic factors and reduced neuroinflammation in the brain. However, the mechanisms underlying the antidepressant effects of NYT and exercise in PSD remain unclear. Therefore, we examined the effects of NYT and physical exercise in a rat model of PSD.
Methods: Rats were divided into five groups: PSD, PSD with NYT, PSD with exercise (Ex), PSD with NYT and exercise (NYT + Ex), and control (sham). PSD was induced by the microinjection of endothelin-1 into the left medial prefrontal cortex and chronic unpredictable mild stress 3 days per week. A diet containing 3% NYT was administered to rats one day after stroke induction. Exercise was conducted using a motorized treadmill for three days per week, starting three days after the stroke. The therapeutic interventions lasted for four weeks. Serum corticosterone levels, depression-like behavior, and hippocampal pathophysiology, including the expression of brain-derived neurotrophic factor (BDNF), precursor BDNF (proBDNF), doublecortin (DCX), NeuN, glial cell activation, and tumor necrosis factor-α (TNF-α), were examined.
Results: Serum corticosterone levels were lower in the treatment group than those in the PSD group. Notably, serum corticosterone levels were significantly lower in the NYT group than those in the PSD group. BDNF expression in the CA1 region was significantly higher in the Ex group than that in the PSD group. The NYT + Ex group showed a significantly higher hippocampal BDNF/proBDNF ratio than the other groups. DCX and NeuN expression levels were significantly higher in the NYT + Ex group than those in the NYT and PSD groups. Hippocampal glial cell activation and TNF-α expression increased in the PSD group and decreased in the intervention groups.
Conclusions: NYT ameliorates serum corticosterone levels and hippocampal neuroinflammation in PSD. Additionally, this study suggested that NYT, together with exercise therapy, may improve neurogenesis, the BDNF/proBDNF ratio, and neuroinflammation in the hippocampus in PSD. |
|
内容記述言語 |
en |
| 要約 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
The version of record of this article, first published in [BMC Complementary Medicine and Therapies], is available online at Publisher’s website: https://doi.org/10.1186/s12906-025-04915-w |
|
内容記述言語 |
en |
| 収録雑誌名 |
en : BMC Complementary Medicine and Therapies
巻 25,
p. 171,
発行日 2025-05-13
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| 作成日 |
|
|
日付 |
2025-05-13 |
|
日付タイプ |
Issued |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
ISSN |
2662-7671 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
DOI |
https://doi.org/10.1186/s12906-025-04915-w |
| 権利 |
|
|
権利情報 |
© The Author(s) 2025. |
|
権利情報の言語 |
en |
| 権利 |
|
|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
|
権利情報の言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 公開者・出版者 |
|
|
出版者 |
Springer Nature |
|
出版者言語 |
en |
| 助成情報 |
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|
助成機関名 |
Tsumura & Co. |
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|
言語 |
en |
| 助成情報 |
|
|
|
助成機関識別子タイプ |
e-Rad_funder |
|
|
助成機関識別子 |
1025 |
|
|
助成機関識別子タイプURI |
https://www.erad.go.jp/datasets/files/haibunkikan.csv |
|
|
助成機関名 |
独立行政法人日本学術振興会 |
|
|
言語 |
ja |
|
|
助成機関名 |
Japan Society for the Promotion of Science |
|
|
言語 |
en |
|
|
言語 |
ja |
|
|
プログラム情報 |
科学研究費助成事業 |
|
|
研究課題番号タイプ |
JGN |
|
|
研究課題番号 |
JP20H04039 |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H04039/ |
|
|
研究課題名 |
脳梗塞前後のコンディショニングによる神経保護機序の解明と脳卒中リハビリへの応用 |
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|
言語 |
ja |
|
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研究課題名 |
Adaptation of the neuroprotective mechanism by conditioning after cerebral ischemia and its application to stroke rehabilitation |
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|
言語 |
en |
| 助成情報 |
|
|
|
助成機関識別子タイプ |
e-Rad_funder |
|
|
助成機関識別子 |
1025 |
|
|
助成機関識別子タイプURI |
https://www.erad.go.jp/datasets/files/haibunkikan.csv |
|
|
助成機関名 |
独立行政法人日本学術振興会 |
|
|
言語 |
ja |
|
|
助成機関名 |
Japan Society for the Promotion of Science |
|
|
言語 |
en |
|
|
言語 |
ja |
|
|
プログラム情報 |
科学研究費助成事業 |
|
|
研究課題番号タイプ |
JGN |
|
|
研究課題番号 |
JP24K02799 |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02799/ |
|
|
研究課題名 |
コンディショニングによる脳保護を考慮した予防リハビリテーションの構築 |
|
|
言語 |
ja |
BMC_Complement.Med.Ther_25_171.pdf (2.2 MB)
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