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磁性、光触媒および光熱ナノ粒子の開発と評価およびがん治療への応用
http://hdl.handle.net/10232/12638
http://hdl.handle.net/10232/12638789bb25c-3322-40f0-ae30-fe1b6e03b1dc
| 名前 / ファイル | ライセンス | アクション |
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rikouken362.pdf (740.8 kB)
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Md. Shariful Islam PhD Thesis_2012.pdf (14.1 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-02-18 | |||||
| タイトル | ||||||
| タイトル | Development and Evaluation of Magnetic, Photocatalytic and Photothermal Nanoparticles and their Application to Cancer Therapy | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 磁性、光触媒および光熱ナノ粒子の開発と評価およびがん治療への応用 | |||||
| タイトル言語 | ja | |||||
| 著者 |
モハッマド シャリフル イスラム
× モハッマド シャリフル イスラム |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | In this thesis, we present a series of different novel experimental techniques for the synthesis of various magnetic, photocatalytic and photothermal nanoparticles with the aim of using them to cancer therapy. We adopted HeLa cells as a model to investigate the thermalphotocatalytic cancer cell killing efficiency of as-synthesized nanomaterials. Furthermore, for the first time we assembled and used combined instrumentation modeling of AC (alternating current) magnetic-field induction and photoexcitation. Nanosized neck-structured and rose type nanoplates of three types of iron oxides (Fe_3O_4, γ-Fe_2O_3 and α-Fe_2O_3) were successfully synthesized by a simple hydrothermal decomposition. Furthermore, Fe_3O_4@TiO_2 core-shell nanocomposites were successfully prepared and their thermal-photocatalytic cell killing efficiency was observed. We also synthesized mixed α and γ-Fe_2O_3 nanoparticles and their synergistic toxic effect against HeLa cells were investigated under AC (alternating current) magnetic-fields induction and photoirradiation conditions at room temperature. Besides we prepared three types of iron oxides (Fe_3O_4, γ-Fe_2O_3 and α-Fe_2O_3) by a co-precipitation method and a comparative study was followed in respects of shape, size, structure and other morphological and magnetic properties. We successfully prepared Cu-TiO_2 nanocomposites. The catalytic activity of the Cu-TiO_2 nanocomposites was evaluated by the application to the photocatalytic cancer (HeLa) cell-killing under UV-visible light irradiation. The Cu-TiO_2 nanocomposites showed higher photocatalytic activity than commercial TiO_2 (P25) under the similar experimental conditions. The Ag metal core-TiO_2 shell (Ag@TiO_2) composite nanoclusters with uniform size, shape and core-shell structures were successfully synthesized by a new simple citrate reduction method. The photocatalytic and photothermal cell killing efficiency of colloidal Ag@TiO_2 core-shell nanoclusters was evaluated against cancer (HeLa) cells under UV–vis irradiation. It was found that the Ag@TiO_2 nanoclusters with an adequate Ag ratio to TiO_2 killed more malignant (HeLa) cells by 80% compared to TiO_2 nanoparticles alone. Finally, from the thorough observations during this research tenure it can be concluded that our synthesized various kinds of nanomaterials whether magnetic, photocatalytic or photothermal showed the great potential use in cancer therapy. |
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| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 理工学研究科博士論文 (工学) ; 学位取得日: 平成24年3月23日 | |||||
| 内容記述言語 | ja | |||||
| 作成日 | ||||||
| 日付 | 2012-03-23 | |||||
| 日付タイプ | Issued | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 431 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 学位論文の要旨, 学位論文本文 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Kagoshima University | |||||
| 出版者言語 | en | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 指導教員: 藏脇淳一 | |||||
| 学位記番号 | ||||||
| 学位記番号 | 理工研第362号 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(工学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Engineering | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2012-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲理工研第362号 | |||||
