WEKO3
アイテム
神経系の骨芽細胞分化・機能への関与について
http://hdl.handle.net/10232/26726
http://hdl.handle.net/10232/2672643a81536-f2dc-4103-b56e-3cdb2153cb17
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
35_p45-52.pdf (1.5 MB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2016-05-13 | |||||||||
| タイトル | ||||||||||
| タイトル | 神経系の骨芽細胞分化・機能への関与について | |||||||||
| タイトル言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Involvement of nervous system on the osteoblastic differentiation and function | |||||||||
| タイトル言語 | en | |||||||||
| 著者 |
後藤, 哲哉
× 後藤, 哲哉
|
|||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Induced pluripotent stem cells | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | osteoblastic cells | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | sympathetic nervous system | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | sensory nervous system | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | neuropeptide receptors | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 要約 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Recently the relationships between nervous system and bone metabolism have been revealed. Though recent evidences suggest that both sympathetic and sensory nerves affect bone metabolism, little is known about the involvement of neuropeptides on the differentiation of stem cells into osteoblastic (OB) cells. The aim of our study was to investigate the expression patterns of neuropeptide receptors at each differentiation stage to evaluate the putative effects of neuropeptides during the differentiation from mouse induced pluripotent stem (iPS) cells, embryoid bodies (EBs), to calcified tissueforming OB cells. Among neuropeptide receptors, β2-adrenergic receptor (AR) and calcitonin gene-related peptide receptor (CGRP-R) were expressed at all stages of cell differentiation, including the iPS cell stage, with peak expression occurring at the early osteoblastic differentiation stage. Another sensory nervous system receptor, neurokinin 1-R (NK1-R), was expressed mainly in the late osteoblastic differentiation stage. Furthermore, the expression of CGRP-R mRNA showed an additional small peak corresponding to EBs cultured for 3 days, suggesting that EBs may be affected by serum CGRP. These evidences suggest that the sympathetic nervous system receptor β2-AR and the sensory nervous system receptor CGRP-R may be involved in the differentiation of iPS cells into the osteoblastic lineage. NK1-R is likely to involve the late stage of osteoblastic cell differentiation. In other words each neuropeptide has an optimal period for the influence during the differentiation process of osteoblastic cells. | |||||||||
| 内容記述言語 | en | |||||||||
| 収録雑誌名 |
ja : 鹿児島大学歯学部紀要 巻 35, p. 45-52, 発行日 2015-03-25 |
|||||||||
| 作成日 | ||||||||||
| 日付 | 2015-03-25 | |||||||||
| 日付タイプ | Issued | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| ISSN | 03897834 | |||||||||
| NII書誌ID（雑誌） | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| NC ID | AN0035442X | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| NDC | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 491.31 | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | 鹿児島大学 | |||||||||
| 出版者言語 | ja | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | Kagoshima University | |||||||||
| 出版者言語 | en | |||||||||
