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降圧療法は,脂肪肝炎を誘導した高血圧モデルラットのインスリン抵抗性,および血清中のIL-6とIL-10濃度を改善する
http://hdl.handle.net/10232/28321
http://hdl.handle.net/10232/283214da893c5-75e3-4edc-a38a-1cdd432e6742
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Diss_小薗_雅哉_ISK366_2016 (745.1 kB)
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Abstract_小薗_雅哉_4511800021_2015 (81.8 kB)
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Result_Kozono_Masaya_isk366_2015.pdf (124.0 kB)
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Comments_Kozono_Masaya_isk366_2015.pdf (67.4 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-09-09 | |||||
| タイトル | ||||||
| タイトル | Antihypertensive therapy improves insulin resistance and serum levels of interleukin-6 and -10 in spontaneously hypertensive rats with steatohepatitis | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 降圧療法は,脂肪肝炎を誘導した高血圧モデルラットのインスリン抵抗性,および血清中のIL-6とIL-10濃度を改善する | |||||
| タイトル言語 | ja | |||||
| 著者 |
小薗, 雅哉
× 小薗, 雅哉 |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Metabolic syndrome based on insulin resistance (IR) and hypertension is a risk factor for advanced liver disease and cardiovascular disease in patients with nonalcoholic steatohepatitis (NASH). The present study investigated the effects of severe hypertension induced by a high‑salt (HS) diet and antihypertensive therapy on the pathophysiological condition of spontaneously hypertensive rats (SHRs) with steatohepatitis. Steatohepatitis was induced using a choline-deficient, L-amino acid-defined diet (CDAA). Male SHRs (7‑week‑old) were randomly divided into five groups: Those receiving 6 weeks of standard chow with a normal salt concentration, followed by an additional 8 weeks of standard chow or CDAA with a normal salt concentration (control and CDAA groups, respectively); and those receiving 6 weeks of standard chow with HS, followed by CDAA with HS for an additional 8 weeks, with or without the antihypertensive agents, amlodipine (Aml) or hydralazine. In the CDAA and CDAA+HS groups, blood pressure was significantly correlated with serum levels of insulin, fasting blood glucose and homeostasis model assessment (HOMA)‑IR. Antihypertensive therapy ameliorated the elevated glucose, insulin and HOMA‑IR. Furthermore, the increased levels of serum interleukin (IL)‑6 following the CDAA+HS diet were attenuated by antihypertensive therapy. The serum levels of IL‑10 were increased by antihypertensive therapy, and the decrease in the proportion of splenic CD4+CD25+forkhead box P3+ T cells observed following the CDAA+HS diet tended to be restored by Aml. In conclusion, antihypertensive therapy improved glucose metabolism and imbalances in cytokine expression in the rat model of hypertension with steatohepatitis, suggesting that antihypertensive therapy acting through immunological factors may be beneficial for patients with metabolic syndrome-associated NASH. Masaya Kozono, Hirofumi Uto, Rie Ibusuki, Shiho Arima, Kohei Oda, Hiroki Taguchi, Fumisato Sasaki, Yuichiro Nasu, Shinichi Hashimoto, Hitoshi Setoyama, Shuji Kanmura, Masatsugu Numata, Hirohito Tsubouchi, Akio Ido Antihypertensive therapy improves insulin resistance and serum levels of interleukin-6 and -10 in spontaneously hypertensive rats with steatohepatitis MOLECULAR MEDICINE REPORTS 14: 5385-5394, 2016 https://doi.org/10.3892/mmr.2016.5875 |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2016-01-01 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Spandidos Publications | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:井戸章雄】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2016-02-03 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-03-25 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第366号 | |||||
