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口腔Bacteroidesと歯周組織のサイトカインネットワーク : 歯周病の機序試論
http://hdl.handle.net/10232/341
http://hdl.handle.net/10232/3412e632e92-3fc8-4b7d-8c29-f07d42b50179
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000165758.pdf (1.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2015-06-04 | |||||||||
| タイトル | ||||||||||
| タイトル | 口腔Bacteroidesと歯周組織のサイトカインネットワーク : 歯周病の機序試論 | |||||||||
| タイトル言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Oral Bacteroides and Cytokine Network in Periodontal Tissues : A Possible Mechanism of Periodontal Diseases | |||||||||
| タイトル言語 | en | |||||||||
| 著者 |
高田, 春比古
× 高田, 春比古
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | bacteroides | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Lipopolysaccharide | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Cytokine network | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Fibroblast | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Interleukin 1 | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 要約 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Oral Bacteroides species represented by Bacteroides (Porphyromonas) gingivalis and Bacteroides intermedius (Prevotella intermedia), which are predominant in subgingival plaques of adult periodontitis patients and are possible periodontopathic bacteria, possess bioactive materials such as cytoplasmic membranes, peptidoglycans, outer membrane proteins, lipopolysaccharides (LPS), capsules, and fimbriae on their cell surfaces. These materials may modulate the cytokine network in periodontal tissues and induced excessive production of cytokines. Some cytokines are involed in inflammatory as well as immunological responses, and are designated as inflammatory cytokines. Among the inflammatory cytokines, interleukin (IL) I has been the most extensively studied, and its existence in periodontal tissues of periodontitis patients and its etiological correlation with periodontitis have been well demonstrated. We found that oral Bacteroides LPS, but not other LPS, induced cell-associated IL-1 α and cell-free IL-1β and IL-6 in normal human gingival fibroblast cultures. The fibroblasts primed with some cytokines, including interferon (IFN)-β, IFN-γ and tumor necrosis factor, produced much higher cell-associated IL-1 α than the non-primed fibroblasts upen stimulation with Bacteroides LPS. The IL-1 is capable of inducing proliferation, matrice formation, and production various cytokines such as IL-1 itself, IL-6,IL-8,colony stimulating factors in fibroblasts themselves and other cells in periodontal tissues. These cytokines in turn augment the inflammatory responses in periodontal tissues. This vicious cascade may be involved in the initiation and development of periodontal diseases characterized by localized chronic inflammation accompanying bone resorption. | |||||||||
| 内容記述言語 | en | |||||||||
| 収録雑誌名 |
ja : 鹿児島大学歯学部紀要 巻 11, p. 1-18, 発行日 1991-03-26 |
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| 作成日 | ||||||||||
| 日付 | 1990-03-25 | |||||||||
| 日付タイプ | Issued | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| ISSN | 03897834 | |||||||||
| NII書誌ID（雑誌） | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| NC ID | AN0035442X | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| NDC | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 497 | |||||||||
| NIIsubject | ||||||||||
| 主題言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 歯学 | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | 鹿児島大学 | |||||||||
| 出版者言語 | ja | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | Kagoshima University | |||||||||
| 出版者言語 | en | |||||||||
