WEKO3
アイテム
加齢と癌,とくに口腔癌
http://hdl.handle.net/10232/344
http://hdl.handle.net/10232/3442ac80cc3-5275-4ba7-82ed-116c5ca211cd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000165765.pdf (708.4 kB)
|
|
| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2015-05-01 | |||||||||
| タイトル | ||||||||||
| タイトル | 加齢と癌,とくに口腔癌 | |||||||||
| タイトル言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Relationship between aging and cancer in men and animals with special consideration on oral carcinoma | |||||||||
| タイトル言語 | en | |||||||||
| 著者 |
浦郷, 篤史
× 浦郷, 篤史
|
|||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 要約 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | There are many evidences that incidence of cancer, especially of oral and lip carcinoma in human increases with age. Notwithstanding considerable variations in types of the spontaneous tumors, experimental animals also demonstrate age-related increase in tumor incidence. The available data on a number of experiments involving administration of chemical carcinogenic agents to laboratory animals of different ages are inconsistent and rather controversial, because age-related decrease and increase in the sensitivity of cells and tissues to the carcinogen or no effect of age at all are widely observed. Metabolic activation and/or inactivation of a carcinogenic compound is undoubtedly one of the most important factors modifying the effect of aging on carcinogenesis. In the recent analyses, age-related changes in the activity of enzymes metabolizing carcinogens determine the effective dose of a damaging agent or its active metabolite. Nevertheless, it seems that at present the related data are too scarce to postulate a leading role for the age-related dynamics of carcinogen. It is also discussed in this paper that during normal life, radom heritable changes may occur by accident in many cells. When certain such changes are fully accumulated in a single (or a small number of) particular cell, the result may be proliferation into a recognizable cancer. However, of all the heritable changes that might occur in a cell, the majority will presumably ignoring lethal changes and irrelevant to carcinogenesis. In old age most cells must have suffered many non-lethal heritable changes by the same general mechanisms being involved in carcinogenesis. Many investigators have suggested that this accumulation of somatic changes is the fundamental process of aging. These random heritable changes arised in the particular cells of an organism would presumably affect not only the timespan of aging, but also that of carcinogenesis. If this is true, the age-associated accumulation of a carcinogenic dose acquired for tumor induction in susceptible individuals is a priori an important factor of an increase of frequency of cancer in old ages, even if aging itself does not affect carcinogenesis. | |||||||||
| 内容記述言語 | en | |||||||||
| 収録雑誌名 |
ja : 鹿児島大学歯学部紀要 en : Annals of Kagoshima University Dental School 巻 12, p. 1-14, 発行日 1992-03-25 |
|||||||||
| 作成日 | ||||||||||
| 日付 | 1992-03-25 | |||||||||
| 日付タイプ | Issued | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| ISSN | 03897834 | |||||||||
| NII書誌ID（雑誌） | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| NC ID | AN0035442X | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| NDC | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 497 | |||||||||
| NIIsubject | ||||||||||
| 主題言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 歯学 | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | 鹿児島大学 | |||||||||
| 出版者言語 | ja | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | Kagoshima University | |||||||||
| 出版者言語 | en | |||||||||
