{"_buckets": {"deposit": "ce9ac40f-4b92-49ce-8fc0-71a85650e861"}, "_deposit": {"created_by": 3, "id": "5997", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "5997"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00005997", "sets": ["135"]}, "author_link": ["106325", "29242", "106324"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Elucidation of mechanisms for controlling stage conversion of Toxoplasma gondii"}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "トキソプラズマ ゲンチュウ ノ ステージ ヘンカン オ セイギョ スル ブンシ キコウ ノ カイメイ"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2014-06-03"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2012-2013年度科学研究費助成事業（若手研究（B））研究成果報告書　課題番号：24780295　研究代表者：正谷達謄（鹿児島大学・獣医学部・助教）", "subitem_description_type": "Other"}, {"subitem_description": "トキソプラズマ原虫は宿主内でシストを形成し、潜伏感染する。この際、増殖型ステージであるタキゾイトと呼ばれる虫体から、潜伏型ステージであるブラディゾイトにステージ変換する。本研究では、このステージ変換に関わる原虫側の種々の蛋白質のクローニング、性状解析を試みた。一方、ステージ変換が起こる際、宿主側の抗ウイルス応答（インターフェロン誘導性蛋白質、OAS1、Mx1およびISG15など）が亢進していることを見いだした。さらなる解析の結果、トキソプラズマ潜伏感染細胞及び潜伏感染動物ではウイルス感染に対して抵抗性を有することが示唆された。", "subitem_description_type": "Other"}, {"subitem_description": "Toxoplasma gondii (T. gondii), an obligate intracellular protozoa, has ability to differentiate from a rapidly replicating tachyzoite stage (Tz) during acute infection to a dormant bradyzoite stage (Bz) contained in tissue cysts. In this study, We identified, cloned and characterized some genes increased in Bz stage. On the other hand, we found that expression levels of some interferon (IFN) -inducible anti-viral proteins, such as OAS1, Mxl and ISG15 in Bz-infected cells were higher than those in uninfected and Tz-infected cells. Further analyses suggest that T.gondii latent infected animals and cells  have resistance to viruses.", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "106324", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "マサタニ, タツノリ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "106325", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "MASATANI, Tatsunori"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "493", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "24780295"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "正谷, 達謄"}], "nameIdentifiers": [{"nameIdentifier": "29242", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000070614072", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "24780295_正谷達謄.pdf", "filesize": [{"value": "274.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 274700.0, "url": {"label": "24780295_正谷達謄.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/5997/files/24780295_正谷達謄.pdf"}, "version_id": "249d4f3a-3af5-493f-af1d-45e6e9fcfbeb"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "畜産学", "subitem_subject_scheme": "Other"}, {"subitem_subject": "獣医学", "subitem_subject_scheme": "Other"}, {"subitem_subject": "応用獣医学", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "トキソプラズマ原虫のステージ変換を制御する分子機構の解明", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "トキソプラズマ原虫のステージ変換を制御する分子機構の解明"}]}, "item_type_id": "8", "owner": "3", "path": ["135"], "permalink_uri": "http://hdl.handle.net/10232/23918", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-05-19"}, "publish_date": "2015-05-19", "publish_status": "0", "recid": "5997", "relation": {}, "relation_version_is_last": true, "title": ["トキソプラズマ原虫のステージ変換を制御する分子機構の解明"], "weko_shared_id": 3}