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  1. 掲載誌一覧
  2. 鹿児島大学歯学部紀要
  3. vol. 13
  1. 歯学部
  2. 歯学部・紀要論文

歯周疾患の発症と進行における白血病の役割

http://hdl.handle.net/10232/348
http://hdl.handle.net/10232/348
b8db32f3-acb5-408d-a8b9-1f61d749a81e
名前 / ファイル ライセンス アクション
KJ00000165773.pdf KJ00000165773.pdf (2.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-05-01
タイトル
タイトル 歯周疾患の発症と進行における白血病の役割
タイトルよみ
タイトルよみ シシュウ シッカン ノ ハッショウ ト シンコウ ニオケル ハッケツビョウ ノ ヤクワリ
別言語のタイトル
その他のタイトル Role of the leukocytes in periodontal health and disease
著者 和泉, 雄一

× 和泉, 雄一

WEKO 78578

和泉, 雄一

Search repository
著者よみ
姓名 イズミ, ユウイチ
別言語の著者
姓名 Izumi, Yuichi
言語
言語 jpn
キーワード
主題Scheme Other
主題 Periodontal disease
キーワード
主題Scheme Other
主題 Leukocytes
キーワード
主題Scheme Other
主題 Chemptaxis
キーワード
主題Scheme Other
主題 Lysosomal enzymes
キーワード
主題Scheme Other
主題 Human Leukocyte Antigen
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
要約(Abstract)
内容記述タイプ Other
内容記述 Leukocytes are involved in the cellular and humoral defense of the organism against foreign material. The protective function of the leukocytes is demonstrated by the fact that the patients with leukocyte disorders present unusually rapid and severe periodontal disease. In addition, the patients with early onset or rapidly progressing forms of periodontal disease often exhibit relatively subtle leukocyte defects. Granulocytes, comprised in the leukocytes, have two distinct cytoplasmic lysosomal granules that contain specific enzyme activities capable of degrading bacterial cell walls as well as host tissues. A variety of proteases released from granulocytes may play a destructive role in periodontal tissue components. Much has examined the potential of measuring levels of various substances found in gingival crevicular fluid (GCF) as indicators of periodontal disease progression. The levels of elastase and cathepsin G discharged from lysosome of granulocyte are elevated in the GCF of the patients with gingivitis and periodontitis. The activity of these enzymes is modulated by specific inhibitors either locally or circulating in plasma. Our investigation that examined the possible relationship between periodontal clinical parameters and GCF elastase, cathepsin G and their inhibitor complex levels may be developed to clarify the periodontal disease activity. HLA system, regulating the immune response, have been found to be associated with various diseases, especially autoimmune diseases. Several studies have demonstrated the linkage between HLA system and early onset and rapidly progressing forms of periodontal disease. HLA system may be associated with low or non-responsiveness to plaque bacterial antigens which could result in disease progression.
収録雑誌名 鹿児島大学歯学部紀要

巻 13, p. 19-33, 発行日 1993
作成日
日付 1993-03-25
ISSN
収録物識別子タイプ ISSN
ISSN 0389-7834
NII書誌ID(雑誌)
収録物識別子タイプ NCID
NC ID AN0035442X
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 497
NIIsubject
主題Scheme Other
主題 歯学
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
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