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破骨細胞と関連病変
http://hdl.handle.net/10232/383
http://hdl.handle.net/10232/383b476b589-fd29-4fef-b05f-34caf7cf2076
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000165875.pdf (1.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2015-03-06 | |||||||||
| タイトル | ||||||||||
| タイトル | 破骨細胞と関連病変 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Osteoclast and related diseases | |||||||||
| 言語 | en | |||||||||
| 著者 |
仙波, 伊知郎
× 仙波, 伊知郎
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | osteoclast | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | microenvironment | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | osteopetrosis | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cancer | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | inflammation | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 要約(Abstract) | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Osteoclast is an essential bone cell that is a supporting and driving force of bone function such as remodeling of tissue and calcium metabolism. Osteoclast represents heterogeneous morphology depended on functional activity according with local tissue microenvironment. A genetic and functional disorder of osteoclast directly causes metabolic bone diseases such as osteopetrosis and osteomalasia. Otherwise, in focal non-specific bone diseases such as direct cancer invasion and inflammation, osteoclast also play an important role for development of the diseases. In the review, several examples of the microenvironment that may regulate osteoclast function in bone diseases are represented and discussed. In a case of adult type osteopetrosis, genetically malfunctioned osteoclasts recovered morphologically and functionally in the inflammatory lesion of mandibular osteomyelitis. The genetic disorder may present in a functional control pathway that cross-talking with an inflammatory signaling pathway. Another example, direct bone invasion by oral cancer induced high activation of osteoclasts in the area faced to the cancer foci. The process of osteoclastic activation in the cancer invasion site was directly reduced by irradiation therapy. Finally, in an inflammatory animal model, highly activated osteoclasts showed large and multinucleated morphology even if they detached from bone surface. The evidences suggest local tissue microenvironment of osteoclast is an essential determinant for not only osteoclastogenesis but also functional activation of mature osteoclast. While, as functional depressing mechanism, control of apoptosis in osteoclast is suspected. Further investigation for factors of microenvironment that regulate osteoclast function and morphology in bone diseases is required. | |||||||||
| 言語 | en | |||||||||
| 収録雑誌名 |
ja : 鹿児島大学歯学部紀要 巻 22, p. 25-32, 発行日 2002-03-25 |
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| 作成日 | ||||||||||
| 日付 | 2002-03-25 | |||||||||
| 日付タイプ | Issued | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03897834 | |||||||||
| NII書誌ID（雑誌） | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN0035442X | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| NDC | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 497 | |||||||||
| NIIsubject | ||||||||||
| 言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 歯学 | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | 鹿児島大学 | |||||||||
| 言語 | ja | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | Kagoshima University | |||||||||
| 言語 | en | |||||||||
