WEKO3
アイテム
Streptococcus mutansと唾液タンパク質の反応に及ぼすラクトフェリンの作用
http://hdl.handle.net/10232/396
http://hdl.handle.net/10232/396642993b9-4b92-41de-8484-dd41a7cf39a6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004291797.pdf (692.6 kB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2015-02-09 | |||||||||
| タイトル | ||||||||||
| タイトル | Streptococcus mutansと唾液タンパク質の反応に及ぼすラクトフェリンの作用 | |||||||||
| タイトル言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Effect of lactoferrin on the interaction between Streptococcus mutans and salivary proteins | |||||||||
| タイトル言語 | en | |||||||||
| 著者 |
於保, 孝彦
× 於保, 孝彦
|
|||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | dental caries | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Streptococcus mutans | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | salivary agglutinin | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | lactoferrin | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 要約 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Streptococcus mutans has been implicated as the prime cause of dental caries, one of the most common diseases in humans. In the oral cavity, there are two types of bacterial interaction with salivary components; saliva-induced bacterial aggregation in solution phase, and bacterial adherence to salivary components adsorbed on the tooth surface. As for S. mutans cells, a 190-kDa surface protein antigen of the organism (PAc) is responsible for these interactions. We have recently shown that bovine milk lactoferrin inhibits both the saliva-induced S. mutans aggregation and the adherence of the organism to a salivary film by binding strongly to salivary agglutinin. Using deletion analysis, we also demonstrated that amino acid residues 473 to 538 of lactoferrin (Lf411) are implicated in these activities. Several studies have demonstrated that salivary agglutinin is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and the S. mutow-binding peptide domain on salivary agglutinin was revealed to be SRCRP2 peptide. We have recently shown that both the rPAc of S. mutans and bovine lactoferrin bind to peptide domain SRCRP2 of salivary agglutinin, and that lactoferrin inhibits the interaction between rPAc and SRCRP2. The lactoferrin residues from 480 to 492 are important for this inhibition, and the peptide corresponding to this region could be used as an inhibitor of S. mutans adherence to a salivary film. | |||||||||
| 内容記述言語 | en | |||||||||
| 収録雑誌名 |
ja : 鹿児島大学歯学部紀要 en : Annals of Kagoshima University Dental School 巻 25, p. 17-24, 発行日 2005-03-25 |
|||||||||
| 作成日 | ||||||||||
| 日付 | 2005-03-25 | |||||||||
| 日付タイプ | Issued | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| ISSN | 03897834 | |||||||||
| NII書誌ID（雑誌） | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| NC ID | AN0035442X | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| NDC | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 497 | |||||||||
| NIIsubject | ||||||||||
| 主題言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 歯学 | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | 鹿児島大学 | |||||||||
| 出版者言語 | ja | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | Kagoshima University | |||||||||
| 出版者言語 | en | |||||||||
