ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "1703d4af-dccf-4e51-abc4-1953415f8939"}, "_deposit": {"created_by": 3, "id": "7779", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "7779"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00007779", "sets": ["86", "5129"]}, "author_link": ["125199", "118396", "118397"], "item_5_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "ジヒドロピリジン ユウドウタイ ニヨル タザイ タイセイ ノ コクフク"}]}, "item_5_biblio_info_5": {"attribute_name": "収録雑誌名", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1990", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "234", "bibliographicPageStart": "225", "bibliographicVolumeNumber": "41", "bibliographic_titles": [{"bibliographic_title": "鹿児島大学医学雑誌"}, {"bibliographic_title": "Medical journal of Kagoshima University", "bibliographic_titleLang": "en"}]}]}, "item_5_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "1990-04-25"}]}, "item_5_date_granted_54": {"attribute_name": "学位授与年月日 ", "attribute_value_mlt": [{"subitem_dategranted": "1990-04-25"}]}, "item_5_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "Ten synthetic dihydropyridine analogues were investigated for their ability to reverse drug-resistance in a multidrug-resistant human carcinoma cell line, KB-Cl. Four dihydropyridine analogues completely reversed the resistance, 3 lowered the resistance and 3 had little effect. The radioactive photoactive dihydropyridine calcium channel blocker, [^3H] azidopine, photolabels P-glycoprotein in membrane vesicles from KB-Cl cells. This photolabeling was almost completely inhibited by excess dihydropyridine analogues that reversed or lowered drug-resistance. In contrast, the labeling was not significantly inhibited by analogues that do not reverse resistance. Among other reversing agents, cepharanthine and reserpine inhibited the [^3H] azidopine photolabeling, but thioridazine did not. SDB-ethylenediamine slightly inhibited the labeling at 100μM. An anticancer agent, vinblastine also inhibited the labeling. The correlation between the reversing of the drug-resistance and the inhibition of the [^3H] azidopin photolabeling of P-glycoprotein by dihydropyridine analogues suggests a role for P-glycoprotein in multidrug-resist ance and also the reversing of the resistance by dihydropyridine analogues.", "subitem_description_type": "Other"}, {"subitem_description": "医歯学総合研究科博士論文(医学) ; 学位取得日: 平成2年4月25日", "subitem_description_type": "Other"}]}, "item_5_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "118396", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "カミワタリ, ミキオ"}]}]}, "item_5_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "118397", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "KAMIWATARI, Mikio"}]}]}, "item_5_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.11501/3087517", "subitem_identifier_reg_type": "JaLC"}]}, "item_5_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_5_relation_32": {"attribute_name": "関連(relation)", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://id.ndl.go.jp/bib/000000248056"}]}]}, "item_5_relation_33": {"attribute_name": "関連(isVersionOf)", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dl.ndl.go.jp/info:ndljp/pid/3087517", "subitem_relation_type_select": "URI"}}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0368-5063", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "NII書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00040104", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "495", "subitem_subject_scheme": "NDC"}]}, "item_5_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_5_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_5_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Thesis or Dissertation"}]}, "item_5_text_44": {"attribute_name": "備考", "attribute_value_mlt": [{"subitem_text_value": "指導教員: 永田行博 ; 平成22年度に行われた国立国会図書館の学位論文(博士)デジタル化事業に際し、著者から、学位授与大学において、国立国会図書館から譲渡を受けた学位論文のデジタル化複製物を利用(全文複写提供、公衆送信)に供することの許諾を受けたものです(参考:http://www.ndl.go.jp/jp/aboutus/digitization_theses.html)。"}]}, "item_5_text_45": {"attribute_name": "備考(非公開)", "attribute_value_mlt": [{"subitem_text_value": "20221028_学位授与年月日追記"}]}, "item_5_text_52": {"attribute_name": "学位番号 ", "attribute_value_mlt": [{"subitem_text_value": "医論第861号"}]}, "item_5_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "神渡, 幹夫"}], "nameIdentifiers": [{"nameIdentifier": "125199", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "000000248056.pdf", "filesize": [{"value": "7.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 7000000.0, "url": {"label": "000000248056.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/7779/files/000000248056.pdf"}, "version_id": "e98a27b9-af54-431e-8e08-c7f027ce2643"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "multidrug-resistance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "P-glycoprotein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dihydropyridine analogues", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "ジヒドロピリジン誘導体による多剤耐性の克服", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ジヒドロピリジン誘導体による多剤耐性の克服"}, {"subitem_title": "Overcoming drug resistance in cancer cells with dihydropyridine analogues", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "3", "path": ["86", "5129"], "permalink_uri": "https://doi.org/10.11501/3087517", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-06-04"}, "publish_date": "2015-06-04", "publish_status": "0", "recid": "7779", "relation": {}, "relation_version_is_last": true, "title": ["ジヒドロピリジン誘導体による多剤耐性の克服"], "weko_shared_id": 3}
  1. 掲載誌一覧
  2. 鹿児島大学医学雑誌
  3. vol.41(3)
  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

ジヒドロピリジン誘導体による多剤耐性の克服

https://doi.org/10.11501/3087517
https://doi.org/10.11501/3087517
b50220f9-5105-4459-9187-f9811e52507c
名前 / ファイル ライセンス アクション
000000248056.pdf 000000248056.pdf (7.0 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2015-06-04
タイトル
タイトル ジヒドロピリジン誘導体による多剤耐性の克服
タイトル
タイトル言語 en
タイトル Overcoming drug resistance in cancer cells with dihydropyridine analogues
タイトルよみ
タイトルよみ ジヒドロピリジン ユウドウタイ ニヨル タザイ タイセイ ノ コクフク
著者 神渡, 幹夫

× 神渡, 幹夫

WEKO 125199

神渡, 幹夫

Search repository
著者よみ
姓名 カミワタリ, ミキオ
別言語の著者
姓名 KAMIWATARI, Mikio
言語
言語 jpn
キーワード
主題Scheme Other
主題 multidrug-resistance
キーワード
主題Scheme Other
主題 P-glycoprotein
キーワード
主題Scheme Other
主題 dihydropyridine analogues
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_46ec
資源タイプ thesis
ID登録
ID登録 10.11501/3087517
ID登録タイプ JaLC
要約(Abstract)
内容記述タイプ Other
内容記述 Ten synthetic dihydropyridine analogues were investigated for their ability to reverse drug-resistance in a multidrug-resistant human carcinoma cell line, KB-Cl. Four dihydropyridine analogues completely reversed the resistance, 3 lowered the resistance and 3 had little effect. The radioactive photoactive dihydropyridine calcium channel blocker, [^3H] azidopine, photolabels P-glycoprotein in membrane vesicles from KB-Cl cells. This photolabeling was almost completely inhibited by excess dihydropyridine analogues that reversed or lowered drug-resistance. In contrast, the labeling was not significantly inhibited by analogues that do not reverse resistance. Among other reversing agents, cepharanthine and reserpine inhibited the [^3H] azidopine photolabeling, but thioridazine did not. SDB-ethylenediamine slightly inhibited the labeling at 100μM. An anticancer agent, vinblastine also inhibited the labeling. The correlation between the reversing of the drug-resistance and the inhibition of the [^3H] azidopin photolabeling of P-glycoprotein by dihydropyridine analogues suggests a role for P-glycoprotein in multidrug-resist ance and also the reversing of the resistance by dihydropyridine analogues.
要約(Abstract)
内容記述タイプ Other
内容記述 医歯学総合研究科博士論文(医学) ; 学位取得日: 平成2年4月25日
収録雑誌名 鹿児島大学医学雑誌
en : Medical journal of Kagoshima University

巻 41, 号 3, p. 225-234, 発行日 1990
作成日
日付 1990-04-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 0368-5063
NII書誌ID(雑誌)
収録物識別子タイプ NCID
NC ID AN00040104
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 495
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
関連(relation)
関連(isVersionOf)
識別子タイプ URI
関連識別子 http://dl.ndl.go.jp/info:ndljp/pid/3087517
備考
備考 指導教員: 永田行博 ; 平成22年度に行われた国立国会図書館の学位論文(博士)デジタル化事業に際し、著者から、学位授与大学において、国立国会図書館から譲渡を受けた学位論文のデジタル化複製物を利用(全文複写提供、公衆送信)に供することの許諾を受けたものです(参考:http://www.ndl.go.jp/jp/aboutus/digitization_theses.html)。
学位記番号
医論第861号
学位授与年月日
学位授与年月日 1990-04-25
戻る
0
views
See details
Views

Versions

Ver.1 2023-07-25 10:06:15.805969
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3