WEKO3
アイテム
VENOM COMPONENTS OF Asobara japonica IMPAIR CELLULAR IMMUNE RESPONSES OF HOST Drosophila melanogaster
http://hdl.handle.net/10232/18458
http://hdl.handle.net/10232/18458c5c60e13-0899-4504-8b46-dde1de81681f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HAYAKAWA_AIBP.2013.3.pdf (813.3 kB)
|
|
| Item type | プレプリント / Preprint(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-07-01 | |||||
| タイトル | ||||||
| タイトル | VENOM COMPONENTS OF Asobara japonica IMPAIR CELLULAR IMMUNE RESPONSES OF HOST Drosophila melanogaster | |||||
| タイトル言語 | en | |||||
| 著者 |
降幡, 駿介
× 降幡, 駿介× マツモト, ヒトシ× キムラ, マサヒト× 早川, 洋一 |
|||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | parasitoid wasp | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Drosophila | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cellular immunity | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | lateral oviduct | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | venom | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The endoparasitoid wasp Asobara japonica has highly poisonous venom: the host Drosophila larvae are killed by envenomation at a dose that is naturally injected by the female wasp at parasitism. This insecticidal venom is neutralized, however, because A. japonica introduces lateral oviduct components soon after venom injection at oviposition. Although the venom and lateral oviduct components of this parasitoid have been partially characterized, how the venom components favor successful development of wasp eggs and larvae in the host remains ambiguous. Here, we demonstrated that A. japonica venom did not affect host humoral immune responses, determined as expression of antimicrobial peptide (AMP) genes, but significantly diminished two cellular responses, spreading and phagocytosis, by host hemocytes. Moreover, venom components drastically elevated a serine protease-like activity 4 h after its injection. The lateral oviduct components did not negate the detrimental effects of the venom on host cellular immunities, but significantly reduced the venom-induced elevation of protease activity. Both active factors in venom and lateral oviduct components were roughly characterized as heat-labile substances with a molecular mass of at least 10 kDa. Finally, venom of A. japonica, with a wide host range, was found to be much more toxic than that of Asobara rossica, which has a limited host range. These results reveal that A. japonica venom toxicity allows exploitation of a broader range of host insects because it is essential to overcome cellular immune responses of the host for successful parasitism. | |||||
| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Archives of Insect Biochemistry and Physiology 巻 83, 号 2, p. 86-100, 発行日 2013 |
|||||
| 作成日 | ||||||
| 日付 | 2013-04-19 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 07394462 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AA1063212X | |||||
| PubMed Id | ||||||
| 識別子タイプ | PMID | |||||
| PubMed Id | 23606512 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1002/arch.21093 | |||||
| 権利 | ||||||
| 権利情報の言語 | en | |||||
| 権利情報 | John Wiley & Sons, Inc. | |||||
| 出版タイプ | ||||||
| 出版タイプ | AO | |||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 486 | |||||
| 公開者・出版者 | ||||||
| 出版者 | John Wiley & Sons, Inc. | |||||
| 出版者言語 | en | |||||
| 備考 | ||||||
| 備考言語 | en | |||||
| 備考 | This is the pre-peer reviewed version of the following article: Furihata, S. X., Matsumoto, H., Kimura, M. T. and Hayakawa, Y. (2013), VENOM COMPONENTS OF Asobara japonica IMPAIR CELLULAR IMMUNE RESPONSES OF HOST Drosophila melanogaster. Arch. Insect Biochem. Physiol., 83: 86–100. doi: 10.1002/arch.21093, which has been published in final form at http://dx.doi.org/10.1002/arch.21093. | |||||
