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Circumstantial and toxicological features of deaths from self-administered intravenous anesthetic/narcotic agents
http://hdl.handle.net/10232/21222
http://hdl.handle.net/10232/2122206809280-9130-4a7f-b529-9e7fee19e850
| 名前 / ファイル | ライセンス | アクション |
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HAYASHI_Re propofol-Blinded Manuscript2.pdf (90.4 kB)
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Re Table 1.pdf (20.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-16 | |||||
| タイトル | ||||||
| タイトル | Circumstantial and toxicological features of deaths from self-administered intravenous anesthetic/narcotic agents | |||||
| タイトル言語 | en | |||||
| 著者 |
林, 敬人
× 林, 敬人× Buschmann, Claas× Riesselmann, Benno× Roscher, Sonja× Tsokos, Michael |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Intravenous anesthetic/narcotic agents | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Self-administration | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Health care professionals | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Propofol | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Therapeutic level | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Respiratory depressant effects | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | For a better understanding of circumstantial and toxicological findings of fatalities resulting from self-administration of intravenous anesthetic/narcotic agents, medico-legal autopsy files of the State Institute of Legal and Social Medicine Berlin from 1998 to 2011 were reviewed retrospectively. Of a total of 15,300 autopsies, 9 cases of such deaths were identified, and all were health care professionals. Medical supplies for injection were found still on, or near, the body at the scene. Anesthetic/narcotic agents detected were classified into 3 categories, and administered solely or in combination. Propofol was the most common agent, being detected in 6 cases. In 2 out of 6 cases, propofol was detected substantially above therapeutic levels and was considered the cause of death. In the remaining 4 cases, propofol levels were within the therapeutic range, but propofol intoxication was considered as lethal due to it being administered by rapid continuous injection. In 5 cases, injection of opioid narcotics was fatal. Alongside the 2 propofol-detected cases, there was one case where a higher-than-therapeutic level of piritramide and a therapeutic level of alfentanil was identified. Despite suspected usage, remifentanil was not detected due to its rapid metabolism by elastases in one case, and sufentanil was undetectable due to putrefaction in another, but death was attributed to their potent respiratory depressant effects without respiratory assistance. Benzodiazepines were detected in 4 cases. All of them were used together with propofol or opioids, and contributed to death by inhibiting respiration. It is essential to consider means of administration as well as additive or synergistic effects of combined agents when interpreting toxicological results in such cases. | |||||
| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Forensic Science, Medicine, and Pathology 巻 9, 号 2, p. 138-144, 発行日 2013 |
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| 作成日 | ||||||
| 日付 | 2013-06-01 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 1547769X | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AA11969333 | |||||
| PubMed Id | ||||||
| 識別子タイプ | PMID | |||||
| PubMed Id | 22926775 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1007/s12024-012-9374-6 | |||||
| 権利 | ||||||
| 権利情報の言語 | en | |||||
| 権利情報 | Springer US | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 498 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Springer US | |||||
| 出版者言語 | en | |||||
| 備考 | ||||||
| 備考 | The final publication is available at link.springer.com | |||||
