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歯周病における歯肉上皮細胞のはたらき
http://hdl.handle.net/10232/373
http://hdl.handle.net/10232/3736d6a9230-f8de-472c-9463-a60e27328167
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000165854.pdf (2.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2015-03-16 | |||||||||
| タイトル | ||||||||||
| タイトル | 歯周病における歯肉上皮細胞のはたらき | |||||||||
| タイトル言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | The role of gingival epithelial cells in periodontal disease progression | |||||||||
| タイトル言語 | en | |||||||||
| 著者 |
和泉, 雄一
× 和泉, 雄一
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | gingival epithelial cells | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | periodontal disease | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cytokine | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | immune response | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | GTR | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 要約 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Gingival epithelium provides the mechanical and biological protective integument of the periodontium. Inflammatory periodontal diseases are characterized by a pathological deepening of the gingival sulcus concomitant with an apical migration of the epithelial attachment and destruction of underlying connective tissue and alveolar bone. These changes result in the formation of a periodontal pocket, lined by pocket epithelium. Histological findings show that the initial inflammatory infiltrate is dominated polymorpho-nuclear leukocytes (PMNs) and T-cells situated immediately beneath the sulcular and junctional epithelia and, at a later stage, pocket epithelium. As the disease progresses, the number of PMNs and T-cells close to the epithelial cells increases. Although much is known concerning immunological mechanisms involved in periodontal disease, the contribution of the gingival epithelial cells to the disease process has not yet been extensively studied. The purpose of the present discussion is to highlight the potential contribution of the gingival epithelial cells to the pathogenesis of periodontal disease. Emphasis will be placed on the complementing a re-cent review on adhesive events between cells of immune system and gingival epithelial cells. The gingival epithelial cells have the capacity to secrete various pro-inflammatory cytokines, such as IL-1 and IL-8,responsible for the influx of PMNs and T-cells, as well as autocrine and paracrine growth and activating factors. Furthermore, activated gingival epithelial cells also have the capacity to act as antigen presenting cells and may thus initiate an immune response by presenting antigens to T-cells. The understanding of the role of the gingival epithelial cells in the pathogenesis of periodontal disease may allow to biological intervention to be part of an early therapeutic approach aimed at preventing disease progression. | |||||||||
| 内容記述言語 | en | |||||||||
| 収録雑誌名 |
ja : 鹿児島大学歯学部紀要 en : Annals of Kagoshima University Dental School 巻 20, p. 5-17, 発行日 2000-03-15 |
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| 作成日 | ||||||||||
| 日付 | 2000-03-15 | |||||||||
| 日付タイプ | Issued | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| ISSN | 0389-7834 | |||||||||
| NII書誌ID（雑誌） | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| NC ID | AN0035442X | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| NDC | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 497 | |||||||||
| NIIsubject | ||||||||||
| 主題言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 歯学 | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | 鹿児島大学 | |||||||||
| 出版者言語 | ja | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | Kagoshima University | |||||||||
| 出版者言語 | en | |||||||||
