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骨芽細胞の分化と機能
http://hdl.handle.net/10232/377
http://hdl.handle.net/10232/377c3faa902-1d4a-4337-91ef-ef5d3e6e7e59
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000165863.pdf (1.7 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2015-03-13 | |||||||||
| タイトル | ||||||||||
| タイトル | 骨芽細胞の分化と機能 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Differentiation and function of osteoblast | |||||||||
| 言語 | en | |||||||||
| 著者 |
田村, 正人
× 田村, 正人
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | transcription factor | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | osteocalcin | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | helix-loop-helix protein | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | osteoblast | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Cbfa1 | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 要約(Abstract) | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Elucidation of molecular mechanisms controlling differentiation and function of osteoblasts is one of the major subjects in bone biology. Differentiation of cells is controlled at the level of transcription by various classes of transcription factors that have been identified through biochemical and genetic means. I showed an expression of rat osteocalcin gene in osteoblasts was mediated by basic helix-loop-helix (bHLH) type of transcription factors. Our study presented evidence that the E-box sequence, OCE1,and transcription factors interacting with this motif, are involved in osteoblast-specific osteocalcin gene transcription. Furthermore, I performed degenerate PCR cloning in order to identify cDNA clones encoding bHLH proteins expressed in osteoblasts. We got clones which sequences in the amplified region were homologous to the mouse twist-related HLH protein, Dermo-1. Dermo-1 mRNA was expressed in osteoblast-1ike cell lines, and could be involved in the osteoblastic differentiation in a negative manner. Current many studies using gene deficient mice revealed how osteoblast differentiation and bone remodeling are controlled through many other type of transcription factors, Cbfal and homeobox protein family. Karsenty et al. showed that Cbfal is necessary for differentiation of mesenchymal progenitor cells to osteoblasts, and Cbfal controls bone formation by differentiated osteoblasts. Extracellular signals including hormones, growth factors, or cytokines as well as their intracellular mediators regulate osteoblast function. In this paper, I reviewed new understandings of the molecular control of osteoblast differentiation and function. | |||||||||
| 言語 | en | |||||||||
| 収録雑誌名 |
ja : 鹿児島大学歯学部紀要 巻 21, p. 15-25, 発行日 2001-03-25 |
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| 作成日 | ||||||||||
| 日付 | 2001-03-25 | |||||||||
| 日付タイプ | Issued | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0389-7834 | |||||||||
| NII書誌ID（雑誌） | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN0035442X | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| NDC | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 497 | |||||||||
| NIIsubject | ||||||||||
| 言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 歯学 | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | 鹿児島大学 | |||||||||
| 言語 | ja | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | Kagoshima University | |||||||||
| 言語 | en | |||||||||
