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Clinical implications of DLL4 expression in gastric cancer
http://hdl.handle.net/10232/20320
http://hdl.handle.net/10232/2032067359227-8c71-4daa-aa53-f106180c11c4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Clinical implications of DLL4 expression in gastric cancer.pdf (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-04-04 | |||||
| タイトル | ||||||
| タイトル | Clinical implications of DLL4 expression in gastric cancer | |||||
| タイトル言語 | en | |||||
| 著者 |
石神, 純也
× 石神, 純也× 有上, 貴明× 上之園, 芳一× 奥村, 浩× 藏原, 弘× 内門, 泰斗× 瀬戸山, 徹郎× 喜多, 芳昭× 喜島, 祐子× 西園, 由香× 中条, 哲浩× 大脇, 哲洋× 上野, 真一× 夏越, 祥次 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Delta-like ligand 4 | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Lymphatic invasion | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Lymph node metastases | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Gastric cancer | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Peritumoral stroma | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor neovascular development and angiogenesis during tumor growth. The clinical significance of DLL4 expression in gastric cancer has not been clarified. Methods: Gastric cancer cell lines and 180 gastric cancer patients were enrolled. DLL4 expression in gastric cancer cells and stroma was identified and evaluated immunohistochemically. The association between DLL4 and clinicopathological factors was also assessed. Results: DLL4 expression was identified in the cellular membrane and cytoplasm of gastric cancer cells by immunoblotting and immunohistochemical staining. DLL4 positivity in cancer cells and stroma was found in 88 (48%) and 41 (22%) of the 180 gastric cancer patients respectively. Both cancer and stromal DLL4 expression significantly correlated with more advanced tumor depth, nodal involvement, and lymphatic and venous invasion. A strongly positive association between cancerous and stromal DLL4 expression was identified (p < 0.01). Both cancerous and stromal DLL4 expression were prognostic markers in gastric cancer as determined by univariate analysis. Conclusions: Cancerous and stromal DLL4 expression was found in 48% and 22% in gastric cancer, and significantly affected postoperative clinical outcomes. Cancerous and stromal DLL4 expression may be an effective target of anti-DLL4 treatment in gastric cancer. |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Journal of Experimental and Clinical Cancer Research 巻 32, p. 46, 発行日 2013-07-30 |
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| 作成日 | ||||||
| 日付 | 2013-07-30 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| ISSN | 17569966 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1186/1756-9966-32-46 | |||||
| 権利 | ||||||
| 権利情報の言語 | en | |||||
| 権利情報 | (C) 2013 Ishigami et al; licensee BioMed Central Ltd. | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
| 公開者・出版者 | ||||||
| 出版者 | BioMed Central | |||||
| 出版者言語 | en | |||||
