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小肝細胞癌の肉眼型分類からみた腫瘍特性 : 細胞増殖能とDoubling Timeの観点から
http://hdl.handle.net/10232/14460
http://hdl.handle.net/10232/144605a6516c8-d76f-48af-bb3d-1bf6d552f773
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00040104_v63n2_p31-35.pdf (916.1 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-01-06 | |||||
| タイトル | ||||||
| タイトル | 小肝細胞癌の肉眼型分類からみた腫瘍特性 : 細胞増殖能とDoubling Timeの観点から | |||||
| タイトル言語 | ja | |||||
| タイトル | ||||||
| タイトル | Tumor cell proliferation and doubling time of small nodular hepatocellular carcinoma based on gross classification | |||||
| タイトル言語 | en | |||||
| 著者 |
上野, 真一
× 上野, 真一× 迫田, 雅彦× 飯野, 聡× 蔵原, 弘× 南, 幸次× 安藤, 慶× 又木, 雄弘× 喜島, 裕子× 前村, 公成× 大脇, 哲弘× 北薗, 正樹× 石神, 純也× 新地, 洋之× 夏越, 祥次 |
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| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Hepatocellular carcinoma | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | MIB-1 | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Doubling time | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Gross classification | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Anatomic resection | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | It is reported that gross classification of hepatocellular carcinoma (HCC) is associated with tumors’ malignant behavior. We studied the characteristics and differences between two types of gross classification of HCCs (i.e. Boundary type: single nodular HCC; Nonboundary type: single nodular with extranodular growth, confluent multinodular, and invasive HCCs) by using MIB-1 labeling index (LI) and tumor volume doubling time (DT). The DT of 87 HCCs, less than 5 cm in diameter at the start of the observation period, was calculated based on ultrasonographic images. The natural progression of the lesions were observed during 1 month or more. Regarding MIB-1 labeling index (LI) of the 87 lesions, we performed immunohistochemical staining (ABC method) with the MIB-1 monoclonal antibody using paraffin-embedded sections obtained by liver resection. The incidence of micrometastasis in the resected sections and the postoperative recurrence ratio were clearly higher in the nonboundary type (n=19) than in the boundary type (n=68). MIB-1 LI and DT were 12.1 +/- 1.3% (mean +/- SE) and 274.8 +/- 36.2 days in the boundary type and 14.2 +/- 2.0% and 103.9 +/- 13.4 days in the nonboundary type. A significant difference of DT was noticed between the 2 groups. These results showed that the nonboundary type HCCs included tumors with rapid growth more than those in the boundary type. Calculating DT would assist in distinguishing gross classification preinterventionally and in determining suitable therapy such as liver resection and ablation. |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
ja : 鹿児島大学医学雑誌 en : Medical journal of Kagoshima University 巻 63, 号 2, p. 31-35, 発行日 2011-09-01 |
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| 作成日 | ||||||
| 日付 | 2011-09-01 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 03685063 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AN00040104 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 494 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Kagoshima University | |||||
| 出版者言語 | en | |||||
