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Contribution of human melanopsin retinal ganglion cells to steady-state pupil responses
http://hdl.handle.net/10232/15997
http://hdl.handle.net/10232/15997f2088c0f-48a0-42e9-a137-466d29501aaf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Tsujimura_Manuscript_Proc.R.Soc.B_v277n1693_p2485-2492.pdf (484.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-02-01 | |||||
| タイトル | ||||||
| タイトル | Contribution of human melanopsin retinal ganglion cells to steady-state pupil responses | |||||
| タイトル言語 | en | |||||
| 著者 |
辻村, 誠一
× 辻村, 誠一× 鵜飼, 一彦× 大濱, 大輔× 塗木, 淳夫× 湯ノ口, 万友 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | melanopsin ganglion cells | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | silent substitution | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | pupil | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | four-primary stimulation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The recent discovery of melanopsin-containing retinal ganglion cells (mRGCs) has led to a fundamental reassessment of non-image forming processing, such as circadian photoentrainment and the pupillary light reflex. In the conventional view of retinal physiology, rods and cones were assumed to be the only photoreceptors in the eye and were, therefore, considered responsible for non-image processing. However, signals from mRGCs contribute to this non-image forming processing along with cone-mediated luminance signals; although both signals contribute, it is unclear how these signals are summed. We designed and built a novel multi-primary stimulation system to stimulate mRGCs independently of other photoreceptors using a silent-substitution technique within a bright steady background. The system allows direct measurements of pupillary functions for mRGCs and cones. We observed a significant change in steady-state pupil diameter when we varied the excitation of mRGC alone, with no change in luminance and colour. Furthermore, the change in pupil diameter induced by mRGCs was larger than that induced by a variation in luminance alone: that is, for a bright steady background, the mRGC signals contribute to the pupillary pathway by a factor of three times more than the L- and M-cone signals. | |||||
| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Proceedings of the Royal Society. B, Biological sciences 巻 277, 号 1963, p. 2485-2492, 発行日 2010 |
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| 作成日 | ||||||
| 日付 | 2010-08-22 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 09628452 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AA11210011 | |||||
| PubMed Id | ||||||
| 識別子タイプ | PMID | |||||
| PubMed Id | 20375057 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1098/rspb.2010.0330 | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| 公開者・出版者 | ||||||
| 出版者 | The Royal Society | |||||
| 出版者言語 | en | |||||
| 備考 | ||||||
| 備考 | Definitive Published Version is available at: http://rspb.royalsocietypublishing.org/ | |||||
