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Inhibitory effect of cyclophilin A from the hard tick Haemaphysalis longicornis on the growth of Babesia bovis and Babesia bigemina
http://hdl.handle.net/10232/21419
http://hdl.handle.net/10232/2141979f09de7-e17f-41fc-a7c7-6fa059ff0729
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Supplementary Figures.pdf (64.9 kB)
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Table.pdf (77.8 kB)
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Figures(revised ver).pdf (112.8 kB)
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manuscript (revised ver).pdf (210.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-24 | |||||
| タイトル | ||||||
| タイトル | Inhibitory effect of cyclophilin A from the hard tick Haemaphysalis longicornis on the growth of Babesia bovis and Babesia bigemina | |||||
| タイトル言語 | en | |||||
| 著者 |
前田, 大輝
× 前田, 大輝× Boldbaatar, Damdinsuren× 草木迫, 浩大× Galay, Remil Linggatong× Aung, Kyaw Min× 白藤（梅宮）, 梨可× 望月, 雅美× 藤崎, 幸蔵× 田仲, 哲也 |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Haemaphysalis longicornis is known as one of the most important ticks transmitting Babesia parasites in East Asian countries, including Babesia ovata and Babesia gibsoni, as well as Theileria parasites. H. longicornis is not the natural vector of Babesia bovis and Babesia bigemina. Vector ticks and transmitted parasites are thought to have established unique host–parasite interaction for their survival, meaning that vector ticks may have defensive molecules for the growth control of parasites in their bodies. However, the precise adaptation mechanism of tick-Babesia parasites is still unknown. Recently, cyclophilin A (CyPA) was reported to be important for the development of Babesia parasites in ticks. To reveal a part of their adaptation mechanism, the current study was conducted. An injection of B. bovis-infected RBCs into adult female H. longicornis ticks was found to upregulate the expression profiles of the gene and protein of CyPA in H. longicornis (HlCyPA). In addition, recombinant HlCyPA (rHlCyPA) purified from Escherichia coli exhibited significant inhibitory growth effects on B. bovis and B. bigemina cultivated in vitro, without any hemolytic effect on bovine RBCs at all concentrations used. In conclusion, our results suggest that HlCyPA might play an important role in the growth regulation of Babesia parasites in H. longicornis ticks, during natural acquisition from an infected host. Furthermore, rHlCyPA may be a potential alternative chemotherapeutic agent against babesiosis. | |||||
| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Parasitology research 巻 112, 号 6, p. 2207-2213, 発行日 2013 |
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| 作成日 | ||||||
| 日付 | 2013-06-01 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 09320113 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AA10682117 | |||||
| PubMed Id | ||||||
| 識別子タイプ | PMID | |||||
| PubMed Id | 23532543 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1007/s00436-013-3390-7 | |||||
| 権利 | ||||||
| 権利情報の言語 | en | |||||
| 権利情報 | Springer-Verlag | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 649 | |||||
| ファイル（説明） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Supplementary Figures, table, figures | |||||
| 言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | Springer-Verlag | |||||
| 出版者言語 | en | |||||
| 備考 | ||||||
| 備考 | The final publication is available at link.springer.com | |||||
