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RBPJ Is a Novel Target for Rhabdomyosarcoma Therapy
http://hdl.handle.net/10232/19981
http://hdl.handle.net/10232/1998175f50b1a-b315-40e4-b779-125f4ee1657f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
RBPJ Is a Novel Target for Rhabdomyosarcoma Therapy.pdf (644.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-12-22 | |||||
| タイトル | ||||||
| タイトル | RBPJ Is a Novel Target for Rhabdomyosarcoma Therapy | |||||
| タイトル言語 | en | |||||
| 著者 |
永尾, 宗子
× 永尾, 宗子× 瀬戸口, 啓夫× 北本, 祥× 石堂, 康弘× 永野, 聡× 横内, 雅博× 棈松, 昌彦× 川畑, 直也× 前田, 真吾× 米澤, 傑× 小宮, 節郎 |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Notch pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. In addition, the Notch pathway plays an important role in controlling tumorigenesis. However, the role of RBPJ, a transcription factor in the Notch pathway, in the development of tumors is largely unknown. In this study, we focused on the role of RBPJ in the pathogenesis of rhabdomyosarcoma (RMS). Our data showed that Notch pathway genes were upregulated and activated in human RMS cell lines and patient samples. Inhibition of the Notch pathway by a csecretase inhibitor (GSI) decreased the in vitro proliferation of RMS cells. Knockdown of RBPJ expression by RNAi inhibited the anchorage-independent growth of RMS cells and the growth of xenografts in vivo. Additionally, overexpression of RBPJ promoted the anchorage-independent growth of RMS cells. Further, we revealed that RBPJ regulated the cell cycle in RMS xenograft tumors and decreased proliferation. Our findings suggest that RBPJ regulates the RMS growth, and that the inhibition of RBPJ may be an effective therapeutic approach for patients with RMS. | |||||
| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : PLoS ONE 巻 7, 号 7, 発行日 2012-07-09 |
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| 作成日 | ||||||
| 日付 | 2012-07-09 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| ISSN | 19326203 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1371/journal.pone.0039268 | |||||
| 権利 | ||||||
| 権利情報の言語 | en | |||||
| 権利情報 | © 2012 Nagao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 494.5 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Public Library of Science | |||||
| 出版者言語 | en | |||||
