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Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma
http://hdl.handle.net/10232/20322
http://hdl.handle.net/10232/203223d7678e3-c81f-4184-abd8-1a7505561d8d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma.pdf (746.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-02-10 | |||||
| タイトル | ||||||
| タイトル | Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma | |||||
| 言語 | en | |||||
| 著者 |
佐々木, 健
× 佐々木, 健× 夏越, 祥次× 石神, 純也× 松本, 正隆× 奥村, 浩× 瀬戸山, 徹郎× 内門, 泰斗× 喜多, 芳昭× 保, 清和× サカモト, アキヒコ× 大脇, 哲洋× 愛甲, 孝 |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 要約(Abstract) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Twist is a basic helix-loop-helix (bHLH) transcriptional factor that has been identified to play an important role in epithelial-mesenchymal transition (EMT)-mediated metastasis through the regulation of E-cadherin expression. However, few authors have examined the expression of Twist and E-cadherin and their prognostic value in patients with esophageal squamous cell carcinoma (ESCC). The purpose of this study is to evaluate the clinical significance of Twist and E-cadherin expression in ESCC. Methods: We immunohistochemically investigated the relationship between their expression and clinicopathological factors including prognosis in surgical specimens of primary tumors in 166 patients with ESCC. Results: The expression rate of high Twist was 42.0% and that of preserved E-cadherin was 40.4%. The expression of high Twist and reduced E-cadherin was significantly associated with depth of tumor invasion, lymph node metastasis, distant nodal metastasis, stage and lymphatic invasion, and poor prognosis. High Twist expression significantly correlated with reduced E-cadherin expression. In the preserved E-cadherin group, the 5-year survival rate was better for patients who were low for Twist expression than for those who were high for Twist expression. Multivariate analysis indicated that the combination of low Twist and preserved E-cadherin expression was an independent prognostic factor along with tumor depth, distant nodal metastasis and E-cadherin expression. Conclusions: Evaluation of Twist and E-cadherin expressions should be useful for determining tumor properties, including prognosis, in patients with ESCC. |
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| 言語 | en | |||||
| 収録雑誌名 |
en : Journal of Experimental and Clinical Cancer Research 巻 28, 号 158, 発行日 2009 |
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| 作成日 | ||||||
| 日付 | 2009-12-21 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 17569966 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1186/1756-9966-28-158 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | (C) 2009 Sasaki et al; licensee BioMed Central Ltd. | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
| 公開者・出版者 | ||||||
| 出版者 | BioMed Central | |||||
| 言語 | en | |||||
