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口腔癌に対する放射線照射併用超選択的動注化学療法の治療効果に関する検討
http://hdl.handle.net/10232/379
http://hdl.handle.net/10232/37978704378-0f54-4c42-a7c1-5ea64da5ea97
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000165865.pdf (1.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2015-03-13 | |||||||||
| タイトル | ||||||||||
| タイトル | 口腔癌に対する放射線照射併用超選択的動注化学療法の治療効果に関する検討 | |||||||||
| タイトル言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Study on the effect of superselective intra-arterial infusion chemotherapy combined with radiation therapy for oral cancer | |||||||||
| タイトル言語 | en | |||||||||
| 著者 |
石神, 哲郎
× 石神, 哲郎
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | tumor blood vessel | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | effect of anticancer agents | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | ultrastructural changes | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | superselective intra-arterial infusion chemotherappy | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | clinico-pathollogical study | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 要約 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Tumor blood vessels are different from the normal capilary vessels in point of the function and anatomical form. They supply not only nutrition and oxygn but also anticancer agents in cases of the chemotherapy. Transplanted VX2 carcinoma in the tongue, treated by bleomycin or non-treated, were investigated ultrastructurally, microangiographically, and injection replica scanning electron microscopically. The results obtained experimentally observed with these methods were interpreted to indicate anticancer agent damages the tumor vascular sysytem when intravenous administration repeated. This harmful effect seemed to be an important factor for controling tumor in clinical practice. Therefore, to reduce the damages for the tumor blood vessel, superselective intra-arterial infusion chemotherapy were administrated for the oral cancer. Because only once administration, it is taken the highly concentraion of the anticancer agent in the tumor tissue and lesser damages for the blood vessels. In adittion, hyperfractionated radiotherapy was combined with simultaneously. This therapy was peroformed on 16 patients. When the irradiation dosage reached about 10Gy, intra-arterial infusion chemotherapy was planned. Angiographic images was obtained into the main feeding artery of the tumor via the femoral artery applied by Seldinger's technique at first. The formula of Calvert is clinically usefull to determin the carboplatin dosage. This method had a remarkable antitumor effect and mild adverse reations. Total response rate was calculated as 100%. As to the histopathological effects of 14 cases examined, Grade Iia was 3 cases, and Grade Iib;4,Grade III;2,Grade IV;5 respectively according to the pathological effects on Oboshi-Shimosato's classification. Regarding the relationship between clinicopathological malignancy and effects of this preoperative treatment, the histopathological response tended to diminish as the malignancy grade became higher. Based on these histopathological findings, it showed that the efficacy of this combination therapy for the primary lesions was high. The curability of the surgical procedures subsequent to this therapy was considered to improve the prognosis of the oral cancer. | |||||||||
| 内容記述言語 | en | |||||||||
| 収録雑誌名 |
ja : 鹿児島大学歯学部紀要 en : Annals of Kagoshima University Dental School 巻 21, p. 35-44, 発行日 2001-03-25 |
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| 作成日 | ||||||||||
| 日付 | 2001-03-25 | |||||||||
| 日付タイプ | Issued | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| ISSN | 03897834 | |||||||||
| NII書誌ID（雑誌） | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| NC ID | AN0035442X | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| NDC | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 497 | |||||||||
| NIIsubject | ||||||||||
| 主題言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 歯学 | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | 鹿児島大学 | |||||||||
| 出版者言語 | ja | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | Kagoshima University | |||||||||
| 出版者言語 | en | |||||||||
