{"_buckets": {"deposit": "c8029245-5556-4e56-bd74-78a44f593575"}, "_deposit": {"created_by": 3, "id": "12709", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "12709"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00012709", "sets": ["83"]}, "author_link": ["74435", "74434", "59777"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Hypoxia-inducible factor -1 is not associated with the clinical course of aplastic anemia in children"}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "サイセイ フリョウセイ ヒンケツ ニオケル HIF-1α オ カイシタ VEGF ノ チョウセツ キコウ ノ カイメイ"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2011-03-31"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2009-2010年度科学研究費補助金(若手研究(B))研究成果報告書 課題番号：21790999　研究代表者：児玉祐一 (鹿児島大学医学部・歯学部附属病院医員)", "subitem_description_type": "Other"}, {"subitem_description": "再生不良性貧血の進行に血小板内のVEGFが関与していることを以前証明したが、今回VEGFの転写因子であるHIF-1αが再生不良性貧血の進行に関与しているかを評価した。再生不良性貧血患者の骨髄の有核細胞を用いてHIF-1αのmRNAの発現量を評価したが、急性に進行する患者と慢性に進行する患者では有意差はなかった。VEGFには別の因子が働いている可能性があることを示唆した。今後巨核球を用いた実験系を確立する予定である。", "subitem_description_type": "Other"}, {"subitem_description": "We assessed the level of hypoxia-inducible factor-1alpha (HIF-1α), which is known to be a transcription factor of VEGF. The mRNA levels of HIF-1α in bone marrow mononuclear cells (BMMC) were measured by real-time PCR in 13 aplastic anemia (AA) patients. HIF-1α in chronic AA patients was not significantly greater than that in acute AA patients. These data indicated that a high level of HIF-1α in chronic AA does not cause the high level of VEGF in a single platelet in chronic AA. The mRNA of HIF-1α in megakaryocytes should be analyzed to better understand the role of HIF-1α in AA.", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "74434", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "コダマ, ユウイチ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "74435", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "KODAMA, Yuichi"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "493", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "21790999"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "児玉, 祐一"}], "nameIdentifiers": [{"nameIdentifier": "59777", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000020535695", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "21790999seika.pdf", "filesize": [{"value": "231.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 231500.0, "url": {"label": "21790999seika.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/12709/files/21790999seika.pdf"}, "version_id": "5c82a312-e477-42c5-89d8-e8833a3df64a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "小児血液学", "subitem_subject_scheme": "Other"}, {"subitem_subject": "VEGF", "subitem_subject_scheme": "Other"}, {"subitem_subject": "再生不良性貧血", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HIF-1α", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "再生不良性貧血におけるHIF-1αを介したVEGFの調節機構の解明", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "再生不良性貧血におけるHIF-1αを介したVEGFの調節機構の解明"}]}, "item_type_id": "8", "owner": "3", "path": ["83"], "permalink_uri": "http://hdl.handle.net/10232/11835", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-01-06"}, "publish_date": "2015-01-06", "publish_status": "0", "recid": "12709", "relation": {}, "relation_version_is_last": true, "title": ["再生不良性貧血におけるHIF-1αを介したVEGFの調節機構の解明"], "weko_shared_id": 3}