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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats.

http://hdl.handle.net/10232/00029969
http://hdl.handle.net/10232/00029969
5a3337a3-8aad-41f2-9d54-030d9ff75d95
名前 / ファイル ライセンス アクション
Diss_Isk442_2017_Shin_Shinyama.pdf Diss_Isk442_2017_Shin_Shinyama (401.8 kB)
Result_Shinyama_Shin_isk442_2017.pdf Result_Shinyama_Shin_isk442_2017 (148.7 kB)
Comments_Shinyama_Shin_isk442_2017.pdf Comments_Shinyama_Shin_isk442_2017 (79.9 kB)
Abstract_新山_新_4506800156_2017.pdf Abstract_新山_新_4506800156_2017 (131.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-01-15
タイトル
タイトル The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats.
別言語のタイトル
その他のタイトル 新生児壊死性腸炎ラットモデルに対する大建中湯の予防効果
著者 新山, 新

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著者よみ
姓名 シンヤマ, シン
別言語の著者
姓名 SHINYAMA, Shin
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 necrotizing enterocolitis
キーワード
主題言語 en
主題Scheme Other
主題 rat model
キーワード
主題言語 en
主題Scheme Other
主題 Daikenchuto
キーワード
主題言語 en
主題Scheme Other
主題 NEC grade
キーワード
主題言語 en
主題Scheme Other
主題 IL-6
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 Purpose: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of premature infants. Daikenchuto, a Japanese herbal drug has several effects on the digestive system, so we investigated its preventive effects in a rat model of NEC.
Methods: NEC was induced in newborn rats via asphyxia (100% N2 for 90 s; every 4 h) + LPS (4 mg/kg/day [administered orally on Days 0 and 1]). The effects of Daikenchuto were evaluated in 4 groups (control: 0 g/kg/day, I: 0.3 g/kg/day, II: 0.6 g/kg/day, III: 1.0 g/kg/day). Daikenchuto was administered into the stomach through a microcatheter. The incidence and severity of NEC were pathologically assessed using the NEC grade in accordance with Dovorak’s previous report. Cell positivity for inflammatory cytokine (IL-6) was also evaluated.
Results: Daikenchuto reduced the incidence of NEC in control, Groups I, II, and III to 68.7%, 30.0%, 30.7%, and 13.3%, respectively. High dose Daikenchuto significantly improved the incidence of NEC, and the rate of IL-6 positive cells in group III was significantly lower than in the control group (p=0.04).
Conclusion: We evaluated the effect of Daikenchuto against NEC and found that it reduced the incidence rate of NEC due to a decrease in the IL-6 production.
収録雑誌名 Pediatric Surgery International

巻 33, 号 10, p. 1109-1114, 発行日 2017-10
情報源
識別子タイプ URI
関連識別子 https://link.springer.com/article/10.1007%2Fs00383-017-4145-9
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 493
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
公開者・出版者
出版者 鹿児島大学
公開者・出版者
出版者 Springer
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
関連(hasPart)
識別子タイプ URI
関連識別子 https://doi.org/10.1007/s00383-017-4145-9
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2017-12-22
学位授与番号
学位授与番号 甲総研第442号
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