{"_buckets": {"deposit": "70110b50-7ec1-418a-8df6-7c3f868dc936"}, "_deposit": {"created_by": 24, "id": "14048", "owners": [24], "pid": {"revision_id": 0, "type": "depid", "value": "14048"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00014048", "sets": ["86"]}, "author_link": ["128902", "128903", "128901"], "item_5_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "新生児壊死性腸炎ラットモデルに対する大建中湯の予防効果"}]}, "item_5_biblio_info_5": {"attribute_name": "収録雑誌名", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "1114", "bibliographicPageStart": "1109", "bibliographicVolumeNumber": "33", "bibliographic_titles": [{"bibliographic_title": "Pediatric Surgery International"}]}]}, "item_5_date_granted_54": {"attribute_name": "学位授与年月日 ", "attribute_value_mlt": [{"subitem_dategranted": "2017-12-22"}]}, "item_5_degree_grantor_53": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "鹿児島大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "17701", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_5_degree_name_42": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）Doctor of Philosophy in Medical Science"}]}, "item_5_description_17": {"attribute_name": "ファイル（説明）", "attribute_value_mlt": [{"subitem_description": "博士論文全文", "subitem_description_type": "Other"}, {"subitem_description": "最終試験結果の要旨", "subitem_description_type": "Other"}, {"subitem_description": "論文審査の要旨", "subitem_description_type": "Other"}, {"subitem_description": "博士論文要旨", "subitem_description_type": "Other"}]}, "item_5_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "Purpose: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of premature infants. Daikenchuto, a Japanese herbal drug has several effects on the digestive system, so we investigated its preventive effects in a rat model of NEC.\nMethods: NEC was induced in newborn rats via asphyxia (100% N2 for 90 s; every 4 h) + LPS (4 mg/kg/day [administered orally on Days 0 and 1]). The effects of Daikenchuto were evaluated in 4 groups (control: 0 g/kg/day, I: 0.3 g/kg/day, II: 0.6 g/kg/day, III: 1.0 g/kg/day). Daikenchuto was administered into the stomach through a microcatheter. The incidence and severity of NEC were pathologically assessed using the NEC grade in accordance with Dovorak’s previous report. Cell positivity for inflammatory cytokine (IL-6) was also evaluated.\nResults: Daikenchuto reduced the incidence of NEC in control, Groups I, II, and III to 68.7%, 30.0%, 30.7%, and 13.3%, respectively. High dose Daikenchuto significantly improved the incidence of NEC, and the rate of IL-6 positive cells in group III was significantly lower than in the control group (p=0.04).\nConclusion: We evaluated the effect of Daikenchuto against NEC and found that it reduced the incidence rate of NEC due to a decrease in the IL-6 production.", "subitem_description_type": "Other"}]}, "item_5_dissertation_number_55": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲総研第442号"}]}, "item_5_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "128902", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "シンヤマ, シン"}]}]}, "item_5_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "128903", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "SHINYAMA, Shin"}]}]}, "item_5_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}, {"subitem_publisher": "Springer"}]}, "item_5_relation_13": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "The final publication is available at link.springer.com"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://link.springer.com/article/10.1007%2Fs00383-017-4145-9", "subitem_relation_type_select": "URI"}}]}, "item_5_relation_36": {"attribute_name": "関連（hasPart）", "attribute_value_mlt": [{"subitem_relation_type": "hasPart", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00383-017-4145-9", "subitem_relation_type_select": "URI"}}]}, "item_5_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "493", "subitem_subject_scheme": "NDC"}]}, "item_5_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_5_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_5_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Thesis or Dissertation"}]}, "item_5_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "新山, 新"}], "nameIdentifiers": [{"nameIdentifier": "128901", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-10-10"}], "displaytype": "detail", 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{"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats."}]}, "item_type_id": "5", "owner": "24", "path": ["86"], "permalink_uri": "http://hdl.handle.net/10232/00029969", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-01-15"}, "publish_date": "2018-01-15", "publish_status": "0", "recid": "14048", "relation": {}, "relation_version_is_last": true, "title": ["The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats."], "weko_shared_id": 24}