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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia

http://hdl.handle.net/10232/00030327
http://hdl.handle.net/10232/00030327
bdde2731-c647-4050-b27c-a543fd81517d
名前 / ファイル ライセンス アクション
Diss_二木_貴弘_ISK472_2018.pdf Diss_二木_貴弘_ISK472_2018 (5.7 MB)
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Abstract_二木_貴弘_4514810228_2018.pdf Abstract_二木_貴弘_4514810228_2018 (72.1 kB)
Result_Futatsuki_Takahiro_isk_472_2018.pdf Result_Futatsuki_Takahiro_isk_472_2018 (682.4 kB)
Comments_Futatsuki_Takahiro_isk_472_2018.pdf Comments_Futatsuki_Takahiro_isk_472_2018 (347.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-09-13
タイトル
タイトル Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia
別言語のタイトル
その他のタイトル 飢餓およびアデノシン誘発低体温へのオレキシン神経の関与
著者 二木, 貴弘

× 二木, 貴弘

WEKO 132091

二木, 貴弘

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著者よみ
姓名 フタツキ, タカヒロ
別言語の著者
姓名 FUTATSUKI, Takahiro
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 We examined whether orexin neurons might play a protective role against fasting- and adenosine-induced hypothermia. We first measured body temperature (BT) in orexin neuron-ablated (ORX-AB) mice and wild-type (WT) controls during 24 hours of fasting. As expected, the magnitude of BT drop and the length of time suffering from hypothermia were greater in ORX-AB mice than in WT mice.
Orexin neurons were active just before onset of hypothermia and during the recovery period as revealed by calcium imaging in vivo using G-CaMP. We next examined adenosine-induced hypothermia via an intracerebroventricular administration of an adenosine A1 receptor agonist, N6-cyclohexyladenosine (CHA), which induced hypothermia in both ORX-AB and WT mice. The dose of CHA required to initiate a hypothermic response in ORX-AB mice was more than 10 times larger than the dose for WT mice. Once hypothermia was established, the recovery was seemingly slower in ORX-AB mice. Activation of orexin neurons during the recovery phase was confirmed by immunohistochemistry for c-Fos. We propose that orexin neurons play dual roles (enhancer in the induction phase and compensator during the recovery phase) in adenosine-induced hypothermia and a protective/compensatory role in fasting-induced hypothermia
収録雑誌名 Scientific Reports

発行日 2018
DOI
識別子タイプ DOI
DOI 10.1038/s41598-018-21252-w
情報源
識別子タイプ URI
関連識別子 https://www.nature.com/srep/
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 491
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 Springer Nature
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:垣花泰之】
date.appl
【学位申請日】2018/5/2
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2018-08-20
学位授与番号
学位授与番号 甲総研第472号
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