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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Risk factors for radiation pneumonitis after stereotactic radiation therapy for lung tumours : clinical usefulness of the planning target volume to total lung volume ratio

http://hdl.handle.net/10232/00030331
http://hdl.handle.net/10232/00030331
a9d2f329-60d8-4343-a0e4-eae71c0278f3
名前 / ファイル ライセンス アクション
Diss_上山_友子_ISK476_2018.pdf Diss_上山_友子_ISK476_2018 (393.3 kB)
Abstract_上山_友子_4510810293_2018.pdf Abstract_上山_友子_4510810293_2018 (193.8 kB)
Result_Ueyama_Tomoko_isk_476_208.pdf Result_Ueyama_Tomoko_isk_476_208 (810.3 kB)
Comments_Ueyama_Tomoko_isk_476_2018.pdf Comments_Ueyama_Tomoko_isk_476_2018 (401.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-09-26
タイトル
タイトル Risk factors for radiation pneumonitis after stereotactic radiation therapy for lung tumours : clinical usefulness of the planning target volume to total lung volume ratio
別言語のタイトル
その他のタイトル 肺腫瘍に対する定位放射線治療における放射線肺炎のリスク因子に関する研究 : 肺体積に占める計画標的体積の割合の臨床的有用性
著者 上山, 友子

× 上山, 友子

WEKO 132103

上山, 友子

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著者よみ
姓名 ウエヤマ, トモコ
別言語の著者
姓名 UEYAMA, Tomoko
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 Objective: To identify risk factors for symptomatic radiation pneumonitis (RP) after stereotactic radiation therapy (SRT) for lung tumours.
Methods: We retrospectively evaluated 68 lung tumours in 63 patients treated with SRT between 2011 and 2015. RP was graded according to the National Cancer Institute—Common Terminology Criteria for Adverse Events version 4.0. SRT was delivered at 7.0–12.0 Gy per each fraction, once daily, to a total of 48–64 Gy (median, 50 Gy). Univariate analysis was performed to assess patient- and treatment-related factors, including age, sex, smoking index (SI), pulmonary function, tumour location, serum Krebs von den Lungen-6 value (KL-6), dose-volume metrics (V5, V10, V20, V30, V40 and VS5), homogeneity index of the planning target volume (PTV), PTV dose, mean lung dose (MLD), contralateral MLD and V2, PTV volume, lung volume and the PTV/lung volume ratio (PTV/Lung). Performance of PTV/Lung in predicting symptomatic RP was also analysed using receiver operating characteristic (ROC) analysis.
Results: The median follow-up period was 21 months. 10 of 63 patients (15.9%) developed symptomatic RP after SRT. On univariate analysis, V10, V20, PTV volume and PTV/Lung were significantly associated with occurrence of RP ≥Grade 2. ROC curves indicated that symptomatic RP could be predicted using PTV/Lung [area under curve (AUC): 0.88, confidence interval (CI: 0.78–0.95), cut-off value: 1.09, sensitivity: 90.0% and specificity: 72.4%].
Conclusion: PTV/Lung is a good predictor of symptomatic RP after SRT.
Advances in knowledge: The cases with high PTV/Lung should be carefully monitored with caution for the occurrence of RP after SRT.
収録雑誌名 British Journal of Radiology

巻 91, 号 1086, 発行日 2018
DOI
識別子タイプ DOI
DOI 10.1259/bjr.20170453
権利
権利情報 © 2018 The Authors. Published by the British Institute of Radiology
情報源
識別子タイプ URI
関連識別子 https://www.birpublications.org/
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 492
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 British Institute of Radiology
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員 : 吉浦敬】
date.appl
【学位申請日】2018-06-06
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2018-09-19
学位授与番号
学位授与番号 甲総研第476号
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