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膠原病患者における運動誘発性肺高血圧症の予測因子の検討
http://hdl.handle.net/10232/00030750
http://hdl.handle.net/10232/00030750ceae2c68-6d6e-4727-bf39-a518d30d6f62
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Diss_宮永_直_ISK514_2019 (566.7 kB)
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Abstract_宮永_直_4514810246_2019 (40.6 kB)
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Result_Miyanaga_Sunao_isk_514 (886.5 kB)
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Comments_Miyanaga_Sunao_isk_514 (445.8 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-08-05 | |||||
| タイトル | ||||||
| タイトル | Predictors of Exercise-lnduced Pulmonary Hypertension in Patients with Connective Tissue Disease | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 膠原病患者における運動誘発性肺高血圧症の予測因子の検討 | |||||
| タイトル言語 | ja | |||||
| 著者 |
宮永, 直
× 宮永, 直 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Exercise-induced pulmonary hypertension | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Connective tissue disease | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Echocardiography | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Right ventricular Tei index | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Screening and early detection of pulmonary arterial hypertension (PAH) in connective tissue disease (CTD) is currently recommended for early treatment. Exercise induced pulmonary hypertension (EIPH) is thought to be a potential risk of developing resting pulmonary hypertension. However, accurately diagnosis of EIPH is needed hemodynamics by right heart catheterization during exercise. Therefore, we compared various parameters of EIPH group with non-EIPH group in patients with CTD. This study aimed to investigate non-invasive predictors of EIPH. A total of 162 consecutive patients with CTD who received screening of PAH was studied. Thirty-four patients with suspected PAH received right heart catheterization (RHC) at rest. Twenty-four patients without PAH underwent RHC during exercise, and they were divided into the EIPH group (n = 7) and the non-EIPH group (n = 17). Exercise tolerance such as 6-minute walk distance and peak VO2/kg in the EIPH group was lower than that in the non-EIPH group. For Hemodynamics, pulmonary artery pressure, right atrial pressure, and vascular resistance in the EIPH group were significantly higher than those in the non-EIPH group. In echocardiography, RV Tei index in the EIPH group was significantly higher than that in the non-EIPH group (EIPH vs non-EIPH = 0.42 [0.41, 0.47] vs 0.25 [0.20, 0.32], P=0.007). The receiver operating characteristics curve showed a cut-off value of RV Tei index (0.41) with a sensitivity of 0.857 and specificity of 0.882. In conclusion, RV Tei index might be a feasible predictor of EIPH in patients with CTD. Sunao Miyanaga, Kayoko Kubota, Noriko Iwatani, Kenjuro Higo, Masaaki Miyata, Yoshihisa Horizoe, Satoko Ojima, Shin Kawasoe, Takuro Kubozono & Mitsuru Ohishi Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease Heart and Vessels, 34, 1509–1518, (2019) This is a post-peer-review, pre-copyedit version of an article published in Heart and Vessels. The final authenticated version is available online at: https://doi.org/10.1007/s00380-019-01373-6 |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Heart and Vessels 巻 34, p. 1509-1518, 発行日 2019 |
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| 作成日 | ||||||
| 日付 | 2019-07-08 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Springer | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | カゴシマ ダイガク | |||||
| 出版者言語 | ja-Kana | |||||
| 備考 | ||||||
| 備考 | 【指導教員:大石充】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2019-04-03 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2019-07-16 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第514号 | |||||
