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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Expression of gremlin1 in gastric cancer and its clinical significance

http://hdl.handle.net/10232/00030840
http://hdl.handle.net/10232/00030840
49b4c32c-cf38-4610-ad00-998f6115d2ad
名前 / ファイル ライセンス アクション
Diss_山﨑_洋一_ISK524_2019.pdf Diss_山﨑_洋一_ISK524_2019 (753.9 kB)
license.icon
Abstract_山﨑_洋一_4513810241_2019.pdf Abstract_山﨑_洋一_4513810241_2019 (145.9 kB)
Result_Yamasaki_Yoichi_isk_524.pdf Result_Yamasaki_Yoichi_isk_524 (1.1 MB)
Comments_Yamasaki_Yoichi_isk_524_2019.pdf Comments_Yamasaki_Yoichi_isk_524_2019 (440.3 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-11-26
タイトル
タイトル Expression of gremlin1 in gastric cancer and its clinical significance
別言語のタイトル
その他のタイトル 胃癌におけるGremlin1の発現と、臨床病理学的意義
著者 山崎, 洋一

× 山崎, 洋一

WEKO 134583

山崎, 洋一

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著者よみ
姓名 ヤマサキ, ヨウイチ
別言語の著者
姓名 YAMASAKI, Yoichi
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 gremlin1
キーワード
主題言語 en
主題Scheme Other
主題 gastric cancer
キーワード
主題言語 en
主題Scheme Other
主題 immunohistochemistry
キーワード
主題言語 en
主題Scheme Other
主題 survival
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 As an antagonist of bone morphogenetic proteins (BMPs) 2, 4 and 7, gremlin1 plays a role in regulating organogenesis, tissue differentiation and angiogenesis. However, there is little information regarding gremlin1 in gastrointestinal cancer. We attempted to clarify how gremlin1 expression affects the clinical features and biological properties of gastric cancer.
A total of 232 gastric cancer patients who received R0 gastrectomy at Kagoshima University Hospital were enrolled. Gremlin1 expression in gastric cancer was detected by immunohistochemical and western blotting methods. Correlations between clinicopathological parameters and gremlin1 expression were analyzed. Gremlin1 was identified in the cytoplasm and nucleus of all gastric cancer cell lines and some regions of surgical specimens of gastric cancer. One hundred and seventeen of the 232 patients (50.4%) were classified as gremlin1-positive based on gremlin 1 expression. Gremlin1 positivity was correlated with shallower tumor depth, smaller tumor size, less nodal involvement and vessel invasion (p<0.05). The 5-year survival rate of the gremlin1-positive group was 81%, which was significantly higher than the gremlin1-negative group (p<0.01). Multivariate analysis revealed that gremlin1 was not selected as an independent prognostic marker. Gremlin1 expression in gastric cancer may be a useful prognostic marker that is involved with the BMP signaling pathway. Furthermore, gremlin1 may have clinical use as a diagnostic and treatment tool.
要約(Abstract)
内容記述タイプ Other
内容記述 Yamasaki, Y., Ishigami, S., Arigami, T. et al.
Expression of gremlin1 in gastric cancer and its clinical significance
Med Oncol (2018) 35: 30.
https://doi.org/10.1007/s12032-017-1073-4
収録雑誌名 Medical Oncology

巻 35, 号 30, 発行日 2018
作成日
日付 2019-11-11
DOI
識別子タイプ DOI
DOI 10.1007/s12032-017-1073-4
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 Springer Nature
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:夏越祥次】
date.appl
【学位申請日】2019-06-05
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2019-11-20
学位授与番号
学位授与番号 甲総研第524号
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