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エストロゲン依存性疾患、外科的去勢および抗がん剤の肌年齢に及ぼす影響(日本人女性での検討)
http://hdl.handle.net/10232/00030843
http://hdl.handle.net/10232/00030843ac4670dc-1413-4ac5-93ae-2a77e25dd003
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Diss_劉_水策_ISK527_2019 (428.9 kB)
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Abstract_劉_水策_4515800164_2019 (142.5 kB)
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Result_Shuice_Liu_isk_527_2019 (1.2 MB)
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Comments_Shuice_Liu_isk_527 (484.8 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-26 | |||||
| タイトル | ||||||
| タイトル | Influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | エストロゲン依存性疾患、外科的去勢および抗がん剤の肌年齢に及ぼす影響(日本人女性での検討) | |||||
| タイトル言語 | ja | |||||
| 著者 |
劉, 水策
× 劉, 水策 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | anti-cancer chemotherapy | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | estrogen-dependent diseases | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | premature oophorectomy | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | skin age | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | skin health conditions | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Aim: The purpose of the present study was to investigate the influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women. Materials and methods: A total of 68 Japanese women were recruited between July 2016 and May 2018 at the Department of Obstetrics and Gynecology, Kagoshima University Hospital. This study included three subjects. Subject 1: A total of 57 premenopausal women were divided into two groups: those with estrogen-dependent diseases (n=19) and estrogen-independent diseases (n=38). Subject 2: A total of 26 premenopausal women were divided into two groups: those with premature oophorectomy (n=15) and ovarian preservation (n=11) during gynecological surgery. Subject 3: A total of 11 postmenopausal women who had received oophorectomy during their cancer operations were divided into two groups: those with postoperative anti-cancer chemotherapy (n=6) and those without chemotherapy (control, n=5). Facial skin parameters including skin age, relative skin age (i.e., skin age minus chronological age) and skin health conditions were assessed using a bioelectrical impedance analysis device. Results: 1) Relative skin age was significantly younger in women with estrogen-dependent diseases than in those with estrogenindependent diseases (-1.0 ± 1.4 vs. 2.5 ± 0.6 years, respectively, p<0.01). 2) Longitudinal changes in relative skin age at 6 months postoperatively in the oophorectomy group had progressed significantly compared with the ovarian preservation group (3.5 ± 1.4 vs. - 0.2 ± 0.8 years, respectively, p<0.05). 3) Longitudinal changes in relative skin age at 12 months after chemotherapy in postmenopausal women who received 6 courses of postoperative anti-cancer chemotherapy had progressed significantly compared with control (10.5 ± 3.3 vs. -3.8 ± 3.4 years, respectively, p<0.05). The ratio of young skin conditions was also significantly decreased after chemotherapy (from 5/6 to 1/6, respectively, p<0.05). Conclusions: Women with estrogen-dependent diseases maintain a younger facial skin age than those with estrogen-independent diseases. However, skin aging is accelerated by premature oophorectomy and markedly accelerated by anti-cancer chemotherapy. LIU Shuice, ORITA Yuji, IWAMOTO Ichiro, SAKIHAMA Mika, TOGAMI Shinichi, OUCHI Tsutomu, KOBAYASHI Hiroaki Influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women Medical journal of Kagoshima University 71(1-3) 23-34, (2019) |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
ja : 鹿児島大学医学雑誌 巻 71, 号 1-3, p. 23-34, 発行日 2019 |
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| 作成日 | ||||||
| 日付 | 2019-11-11 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | カゴシマ ダイガク | |||||
| 出版者言語 | ja-Kana | |||||
| 公開者・出版者 | ||||||
| 出版者 | Kagoshima University | |||||
| 出版者言語 | en | |||||
| 備考 | ||||||
| 備考 | 【指導教員:小林裕明】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2019-08-07 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2019-11-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第527号 | |||||
