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グリチルレチン酸誘導体であるサクシニルグリチルレチン酸ニナトリウムのStreptococcus mutansに対する抗菌効果について
http://hdl.handle.net/10232/00030888
http://hdl.handle.net/10232/000308885494f938-357b-4512-af57-6fe6f2020360
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Diss_山下_剛史_ISK532_2019 (902.2 kB)
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Abstract_山下_剛史_4512800142_2019 (146.5 kB)
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Result_Yamashita_Takahito_isk_532 (556.9 kB)
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Comments_Yamashita_Takahito_isk_532 (225.1 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-13 | |||||
| タイトル | ||||||
| タイトル | Antibacterial activity of disodium succinoyl glycyrrhetinate, a derivative of glycyrrhetinic acid against Streptococcus mutans | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | グリチルレチン酸誘導体であるサクシニルグリチルレチン酸ニナトリウムのStreptococcus mutansに対する抗菌効果について | |||||
| タイトル言語 | ja | |||||
| 著者 |
山下, 剛史
× 山下, 剛史 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Antibacterial agent | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Streptococcus mutans | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Streptococcus mutans is a cariogenic bacterium that localizes in the oral cavity. Glycyrrhetinic acid (GRA) is a major component of licorice extract. GRA and several derivatives, including disodium succinoyl glycyrrhetinate (GR-SU), are known to have anti-inflammatory effects in humans. In this study, the antimicrobial effect of GRA and its derivatives against the S. mutans UA159 strain were investigated. Minimum inhibitory concentrations (MICs) of GRA and GR-SU showed antibacterial activity against the S. mutans strain, whereas other tested derivatives did not. Because GR-SU is more soluble than GRA, GR-SU was used for further experiments. The antibacterial activity of GR-SU against 100 S. mutans strains was evaluated and it was found that all strains are susceptible to GR-SU, with MIC values below 256 µg/mL. A cell viability assay showed that GR-SU has a bacteriostatic effect on S. mutans cells. As to growth kinetics, sub-MICs of GR-SU inhibited growth. The effect of GR-SU on S. mutans virulence was then investigated. GR-SU at sub-MICs suppresses biofilm formation. Additionally, GR-SU greatly suppresses the pH drop caused by the addition of glucose and glucose-induced expression of the genes responsible for acid production (ldh and pykF) and tolerance (aguD and atpD). Additionally, expression of enolase, which is responsible for the carbohydrate phosphotransferase system, was not increased in the presence of GR-SU, indicating that GR-SU suppresses incorporation of sugars into S. mutans. In conclusion, GR-SU has antibacterial activity against S. mutans and also decreases S. mutans virulence. This is the peer reviewed version of the following article: Takahito Yamashita, Miki Kawada-Matsuo, Tamaki Katsumata, Atsuko Watanabe, Yuichi Oogai, Yoshihiro Nishitani, Shouichi Miyawaki, Hitoshi Komatsuzawa. Safety, speed, and effectiveness of air transportation for neonates Microbiology and immunology (2019), 63(7), 251-260 © 2019 The Societies and John Wiley & Sons Australia, Ltd which has been published in final form at https://doi.org/10.1111/1348-0421.12717 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2020-01-14 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | The Societies and John Wiley & Sons Australia, Ltd | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:仙波伊知郎/松尾美樹】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2019-09-04 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(歯学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Dental Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-01-28 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第532号 | |||||
